Jason A Wojcechowskyj
Overview
Explore the profile of Jason A Wojcechowskyj including associated specialties, affiliations and a list of published articles.
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17
Citations
1639
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Recent Articles
1.
Hiatt J, Hultquist J, McGregor M, Bouhaddou M, Leenay R, Simons L, et al.
Nat Commun
. 2022 Apr;
13(1):1752.
PMID: 35365639
Human Immunodeficiency Virus (HIV) relies on host molecular machinery for replication. Systematic attempts to genetically or biochemically define these host factors have yielded hundreds of candidates, but few have been...
2.
Starr T, Czudnochowski N, Liu Z, Zatta F, Park Y, Addetia A, et al.
Nature
. 2021 Jul;
597(7874):97-102.
PMID: 34261126
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape, have activity against diverse sarbecoviruses, and be highly protective through viral neutralization and effector functions. Understanding how these properties relate to...
3.
Hiatt J, Cavero D, McGregor M, Zheng W, Budzik J, Roth T, et al.
Cell Rep
. 2021 May;
35(6):109105.
PMID: 33979618
Genome engineering of primary human cells with CRISPR-Cas9 has revolutionized experimental and therapeutic approaches to cell biology, but human myeloid-lineage cells have remained largely genetically intractable. We present a method...
4.
Starr T, Czudnochowski N, Zatta F, Park Y, Liu Z, Addetia A, et al.
bioRxiv
. 2021 Apr;
PMID: 33851154
An ideal anti-SARS-CoV-2 antibody would resist viral escape , have activity against diverse SARS-related coronaviruses , and be highly protective through viral neutralization and effector functions . Understanding how these...
5.
Thomson E, Rosen L, Shepherd J, Spreafico R, da Silva Filipe A, Wojcechowskyj J, et al.
Cell
. 2021 Feb;
184(5):1171-1187.e20.
PMID: 33621484
SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is...
6.
Tortorici M, Beltramello M, Lempp F, Pinto D, Dang H, Rosen L, et al.
Science
. 2020 Sep;
370(6519):950-957.
PMID: 32972994
Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 September 2020. We...
7.
Patrick K, Wojcechowskyj J, Bell S, Riba M, Jing T, Talmage S, et al.
Cell Syst
. 2018 Aug;
7(3):323-338.e6.
PMID: 30077634
Intracellular bacterial pathogens secrete a repertoire of effector proteins into host cells that are required to hijack cellular pathways and cause disease. Despite decades of research, the molecular functions of...
8.
Riblett A, Blomen V, Jae L, Altamura L, Doms R, Brummelkamp T, et al.
J Virol
. 2015 Nov;
90(3):1414-23.
PMID: 26581979
Unlabelled: Rift Valley fever virus (RVFV) causes recurrent insect-borne epizootics throughout the African continent, and infection of humans can lead to a lethal hemorrhagic fever syndrome. Deep mutagenesis of haploid...
9.
Shah P, Wojcechowskyj J, Eckhardt M, Krogan N
Curr Opin Microbiol
. 2015 Aug;
27:62-8.
PMID: 26275922
Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack...
10.
Wojcechowskyj J, Didigu C, Lee J, Parrish N, Sinha R, Hahn B, et al.
Cell Host Microbe
. 2013 May;
13(5):613-623.
PMID: 23684312
Receptor engagement by HIV-1 during host cell entry activates signaling pathways that can reprogram the cell for optimal viral replication. To obtain a global view of the signaling events induced...