Jason A Lehman
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Explore the profile of Jason A Lehman including associated specialties, affiliations and a list of published articles.
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11
Citations
199
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Recent Articles
1.
Batuello C, Hauck P, Gendron J, Lehman J, Mayo L
Proc Natl Acad Sci U S A
. 2015 Jan;
112(6):1749-54.
PMID: 25624478
Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor protein p53. Mdm2 binds to and is involved...
2.
Lehman J, Hauck P, Gendron J, Batuello C, Eitel J, Albig A, et al.
PLoS One
. 2013 Sep;
8(9):e74741.
PMID: 24040331
Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also regulates numerous proteins involved in diverse...
3.
Lehman J, Mayo L
Int J Mol Sci
. 2012 Dec;
13(12):16373-86.
PMID: 23208375
The alteration of tumorigenic pathways leading to cancer is a degenerative disease process typically involving inactivation of tumor suppressor proteins and hyperactivation of oncogenes. One such oncogenic protein product is...
4.
Lehman J, Waning D, Batuello C, Cipriano R, Kadakia M, Mayo L
J Biol Chem
. 2011 Aug;
286(42):36631-40.
PMID: 21873427
The p53 family member, p73, has been characterized as a tumor suppressor and functions in a similar manner as p53 to induce cellular death. The phosphatase and tensin homolog (PTEN)...
5.
Waning D, Lehman J, Batuello C, Mayo L
J Biol Chem
. 2010 Nov;
286(1):216-22.
PMID: 21081495
Mdm2 and Mdmx are oncoproteins that have essential yet nonredundant roles in development and function as part of a multicomponent ubiquitinating complex that targets p53 for proteasomal degradation. However, in...
6.
Waning D, Lehman J, Batuello C, Mayo L
Pharmaceuticals (Basel)
. 2010 Jul;
3(5):1576-1593.
PMID: 20651945
The p53 tumor suppressor is a key protein in maintaining the integrity of the genome by inducing either cell cycle arrest or apoptosis following cellular stress signals. Two human family...
7.
Lehman J, Eitel J, Batuello C, Mayo L
Expert Opin Drug Discov
. 2009 Sep;
3(11):1309-1321.
PMID: 19738896
BACKGROUND: The mdm2 proto-oncogene is elevated in numerous late stage cancers. The Mdm2 protein manifests its oncogenic properties in part through inactivation of the tumor suppressor protein p53. Recent efforts...
8.
Lehman J, Hoelz D, Turchi J
Biochemistry
. 2008 Mar;
47(15):4359-68.
PMID: 18355052
Ionizing radiation induces DNA double-strand breaks which are repaired by the nonhomologous end joining (NHEJ) pathway. NHEJ is initiated upon Ku binding to the DNA ends and facilitating an interaction...
9.
Andrews B, Lehman J, Turchi J
J Biol Chem
. 2006 Mar;
281(19):13596-13603.
PMID: 16537541
Ku is a heterodimeric protein comprising 70- and 80-kDa subunits that participate in the non-homologous end-joining (NHEJ) repair pathway for rejoining DNA double strand breaks. We have analyzed the pre-steady...
10.
Lehman J, Calvo V, Gomez-Cambronero J
J Biol Chem
. 2003 May;
278(30):28130-8.
PMID: 12740386
We report here for the first time the detection of the ribosomal p70S6 kinase (p70S6K) in a hematopoietic cell, the neutrophil, and the stimulation of its enzymatic activity by granulocyte...