Jarvier N Mohammed
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Explore the profile of Jarvier N Mohammed including associated specialties, affiliations and a list of published articles.
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12
Citations
100
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Recent Articles
1.
A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function
Gelles J, Chen Y, Luna-Vargas M, Follis A, Bayiokos S, Mohammed J, et al.
bioRxiv
. 2025 Jan;
PMID: 39763924
Mitochondria maintain a biochemical environment that cooperates with BH3-only proteins (e.g., BIM) to potentiate BAX activation, the key event to initiate physiological and pharmacological forms of apoptosis. The sphingosine-1-phosphate metabolite...
2.
Chen Y, Gelles J, Mohammed J, Chipuk J
Front Cell Dev Biol
. 2023 Dec;
11:1322816.
PMID: 38143925
Diverse developmental signals and pro-death stresses converge on the regulation of the mitochondrial pathway of apoptosis. BAX, a proapoptotic BCL-2 effector, directly forms proteolipid pores in the outer mitochondrial membrane...
3.
Chen Y, Gelles J, Mohammed J, Chipuk J
bioRxiv
. 2023 Oct;
PMID: 37905126
Diverse developmental signals and pro-death stresses converge on regulation of the mitochondrial pathway of apoptosis. BAX, a pro-apoptotic BCL-2 effector, directly forms proteolipid pores in the outer mitochondrial member to...
4.
Gelles J, Mohammed J, Chen Y, Sebastian T, Chipuk J
Cell Rep Methods
. 2022 Apr;
2(3).
PMID: 35419554
Developmental, homeostatic, and pharmacological pro-apoptotic signals converge by activating the BCL-2 family member BAX. Studies investigating molecular regulation of BAX are commonly limited to methodologies measuring endpoint phenotypes and do...
5.
Mohammed J, Gelles J, Chipuk J
STAR Protoc
. 2022 Mar;
3(2):101252.
PMID: 35313708
BAX activation techniques are crucial to studying the intrinsic pathway of apoptosis- thousands of pro-apoptotic signals converge on BAX activation. Current methodologies are predominantly limited to membrane permeabilization studies, which...
6.
Chipuk J, Mohammed J, Gelles J, Chen Y
Dev Cell
. 2021 Apr;
56(9):1221-1233.
PMID: 33887204
The ancient, dynamic, and multifaceted functions of the mitochondrial network are essential for organismal homeostasis and contribute to numerous human diseases. As central hubs for metabolism, ion transport, and multiple...
7.
Mohammed J, Gelles J, Rubio-Patino C, Serasinghe M, Trotta A, Lockshin R, et al.
FEBS J
. 2020 Mar;
287(11):2201-2211.
PMID: 32147971
In June of 2019, the International Cell Death Society (ICDS) held its 25th anniversary meeting in New York City at the Icahn School of Medicine at Mount Sinai organized by...
8.
Gelles J, Mohammed J, Santos L, Legarda D, Ting A, Chipuk J
Dev Cell
. 2019 Oct;
51(2):277-291.e4.
PMID: 31564612
Quantifying cytostatic and cytotoxic outcomes are integral components of characterizing perturbagens used as research tools and in drug discovery pipelines. Furthermore, data-rich acquisition, coupled with robust methods for analysis, is...
9.
Elkholi R, Abraham-Enachescu I, Trotta A, Rubio-Patino C, Mohammed J, Luna-Vargas M, et al.
Mol Cell
. 2019 Mar;
74(3):452-465.e7.
PMID: 30879903
Signaling diversity and subsequent complexity in higher eukaryotes is partially explained by one gene encoding a polypeptide with multiple biochemical functions in different cellular contexts. For example, mouse double minute...
10.
Luna-Vargas M, Mohammed J, Gelles J, Chipuk J
Methods Mol Biol
. 2018 Dec;
1877:121-130.
PMID: 30536002
Isolated model systems have proven to be the standard in the apoptosis field to deconstruct MOMP into individual steps and to study the behavior of a subset of MOMP regulators....