Jared Carlson-Stevermer
Overview
Explore the profile of Jared Carlson-Stevermer including associated specialties, affiliations and a list of published articles.
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21
Citations
1033
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Recent Articles
1.
Aulston B, Gimse K, Bazick H, Kramar E, Pizzo D, Parra-Rivas L, et al.
bioRxiv
. 2024 Jun;
PMID: 38895278
Gene-editing technologies promise to create a new class of therapeutics that can achieve permanent correction with a single intervention. Besides eliminating mutant alleles in familial disease, gene-editing can also be...
2.
Haas K, McGregor M, Bouhaddou M, Polacco B, Kim E, Nguyen T, et al.
Nat Commun
. 2023 Sep;
14(1):6030.
PMID: 37758692
Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs)....
3.
Chen I, Longbotham J, McMahon S, Suryawanshi R, Khalid M, Taha T, et al.
Cell Rep
. 2022 Jul;
40(3):111088.
PMID: 35839775
Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here we show that BET...
4.
Mac Kain A, Maarifi G, Aicher S, Arhel N, Baidaliuk A, Munier S, et al.
Nat Commun
. 2022 May;
13(1):2442.
PMID: 35508460
Interferon restricts SARS-CoV-2 replication in cell culture, but only a handful of Interferon Stimulated Genes with antiviral activity against SARS-CoV-2 have been identified. Here, we describe a functional CRISPR/Cas9 screen...
5.
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
Samelson A, Tran Q, Robinot R, Carrau L, Rezelj V, Mac Kain A, et al.
Nat Cell Biol
. 2022 Jan;
24(1):24-34.
PMID: 35027731
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways...
6.
Chen I, Longbotham J, McMahon S, Suryawanshi R, Carlson-Stevermer J, Gupta M, et al.
bioRxiv
. 2021 Nov;
PMID: 34816261
Inhibitors of Bromodomain and Extra-terminal domain (BET) proteins are possible anti-SARS-CoV-2 prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here, we show that BET proteins should not be inactivated therapeutically...
7.
Williams C, Jureka A, Silvas J, Nicolini A, Chvatal S, Carlson-Stevermer J, et al.
Cell Rep
. 2021 Jul;
36(5):109479.
PMID: 34320401
Coronaviruses rely on host membranes for entry, establishment of replication centers, and egress. Compounds targeting cellular membrane biology and lipid biosynthetic pathways have previously shown promise as antivirals and are...
8.
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
Samelson A, Tran Q, Robinot R, Carrau L, Rezelj V, Mac Kain A, et al.
bioRxiv
. 2021 Jan;
PMID: 33501440
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways...
9.
Wang R, Simoneau C, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi J, et al.
Cell
. 2020 Dec;
184(1):106-119.e14.
PMID: 33333024
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host factors common to multiple...
10.
Carlson-Stevermer J, Das A, Abdeen A, Fiflis D, Grindel B, Saxena S, et al.
Nat Commun
. 2020 Dec;
11(1):6277.
PMID: 33293555
Compound heterozygous recessive or polygenic diseases could be addressed through gene correction of multiple alleles. However, targeting of multiple alleles using genome editors could lead to mixed genotypes and adverse...