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Janine Stuart

Explore the profile of Janine Stuart including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 27
Citations 382
Followers 0
Related Specialties
Critical Care
Pharmacology
General Medicine
Top 10 Co-Authors
Melissa Lassig-Smith
Therese Starr
Jeffrey Lipman
Jason A Roberts
Steven C Wallis
Paul Jarrett
Saurabh Pandey
Fekade B Sime
Andrew A Udy
Rachel Dunlop
Published In
Antimicrob Agents Chemother
Intensive Care Med
Crit Care
J Crit Care
Anesth Analg
Affiliations
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Recent Articles
1.
Low-dose clonidine infusion to improve sleep in postoperative patients in the high-dependency unit. A randomised placebo-controlled single-centre trial
Liu D, Hallt E, Platz A, Humblet A, Lassig-Smith M, Stuart J, et al.
Intensive Care Med . 2024 Sep; 50(11):1873-1883. PMID: 39311905
Purpose: Dexmedetomidine increases sleep and reduces delirium in postoperative patients, but it is expensive and requires a monitored environment. Clonidine, another 2-agonist, is cheaper and is used safely for other...
2.
PREdiction and Diagnosis using Imaging and Clinical biomarkers Trial in Traumatic Brain Injury (PREDICT-TBI) study protocol: an observational, prospective, multicentre cohort study for the prediction of outcome in moderate-to-severe TBI
Nasrallah F, Bellapart J, Walsham J, Jacobson E, To X, Manzanero S, et al.
BMJ Open . 2023 Apr; 13(4):e067740. PMID: 37094888
Introduction: Traumatic brain injury (TBI) is a heterogeneous condition with a broad spectrum of injury severity, pathophysiological processes and variable outcomes. For moderate-to-severe TBI survivors, recovery is often protracted and...
3.
Diagnosing sepsis in the ICU: Comparison of a gene expression signature to pre-existing biomarkers
Denny K, Lea R, Lindell-Innes R, Haupt L, Heffernan A, Harvey N, et al.
J Crit Care . 2023 Mar; 76:154286. PMID: 36965223
Purpose: We aimed to identify a gene signature that discriminates between sepsis and aseptic inflammation in patients administered antibiotics in the intensive care unit and compare it to commonly utilised...
4.
Diagnostic Sensitivity of Plasma Endothelin-1 for Cerebral Vasospasm After Subarachnoid Hemorrhage, a Multicentre Double-Blind Study
Bellapart J, Nasrallah F, Winearls J, Lassig-Smith M, Stuart J, Boots R, et al.
J Intensive Care Med . 2021 Dec; 37(6):769-775. PMID: 34898303
The purpose of this study is to establish the diagnostic sensitivity of Endothelin-1 for risk stratification and screening of clinical vasospasm after subarachnoid hemorrhage.This is a multicentre, observational study, correlating...
5.
A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane-tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic...
Parker S, Pandey S, Sime F, Stuart J, Lipman J, Roberts J, et al.
Clin Chem Lab Med . 2021 Feb; 59(5):921-933. PMID: 33554515
Objectives: Novel treatment options for some carbapenem-resistant Gram-negative pathogens have been identified by the World Health Organization as being of the highest priority. Ceftolozane-tazobactam is a novel cephalosporin-beta-lactamase inhibitor combination...
6.
What the forks? A longitudinal quality improvement study tracking cutlery numbers in a public teaching and research hospital staff tearoom
Mattiussi M, Livermore A, Levido A, Starr T, Lassig-Smith M, Stuart J, et al.
Med J Aust . 2020 Dec; 213(11):521-523. PMID: 33314112
Objectives: To evaluate the circulation lifespan of forks and teaspoons in an institutional tearoom. Design: Longitudinal quality improvement study, based on prospective tracking of marked teaspoons and forks. Setting: Staff...
7.
Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain
Sime F, Lassig-Smith M, Starr T, Stuart J, Pandey S, Parker S, et al.
Antimicrob Agents Chemother . 2020 Oct; 65(1). PMID: 33077655
The aim of this study was to describe the pharmacokinetics of ceftolozane-tazobactam in plasma and cerebrospinal fluid (CSF) of infected critically ill patients. In a prospective observational study, critically ill...
8.
Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial
Bellapart J, Appadurai V, Lassig-Smith M, Stuart J, Zappala C, Boots R
Crit Care Res Pract . 2020 Oct; 2020:3951828. PMID: 33029397
Introduction: Sleep deprivation is a contributor for delirium in intensive care. Melatonin has been proposed as a pharmacological strategy to improve sleep, but studies have shown that the increase in...
9.
Early Sequential Microcirculation Assessment In Shocked Patients as a Predictor of Outcome: A Prospective Observational Cohort Study
Holley A, Dulhunty J, Udy A, Midwinter M, Lukin B, Stuart J, et al.
Shock . 2020 Aug; 55(5):581-586. PMID: 32826808
Objectives: A dysfunctional microcirculation is universal in shock and is often dissociated from global hemodynamic parameters. Persistent microcirculatory derangements reflect ongoing tissue hypoperfusion and organ injury. The initial microcirculatory dysfunction...
10.
A Population Pharmacokinetic Model-Guided Evaluation of Ceftolozane-Tazobactam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemodiafiltration
Sime F, Lassig-Smith M, Starr T, Stuart J, Pandey S, Parker S, et al.
Antimicrob Agents Chemother . 2019 Oct; 64(1). PMID: 31658965
The aim of this work was to describe optimized dosing regimens of ceftolozane-tazobactam for critically ill patients receiving continuous venovenous hemodiafiltration (CVVHDF). We conducted a prospective observational pharmacokinetic study in...