Jang-Hyun Oh
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Explore the profile of Jang-Hyun Oh including associated specialties, affiliations and a list of published articles.
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10
Citations
481
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Recent Articles
1.
Oh J, Hyun J, Chen S, Varshavsky A
Proc Natl Acad Sci U S A
. 2020 May;
117(20):10778-10788.
PMID: 32366662
The Arg/N-degron pathway targets proteins for degradation by recognizing their N-terminal (Nt) residues. If a substrate bears, for example, Nt-Asn, its targeting involves deamidation of Nt-Asn, arginylation of resulting Nt-Asp,...
2.
Oh J, Chen S, Varshavsky A
J Biol Chem
. 2017 Nov;
292(52):21457-21465.
PMID: 29122887
Although it is widely appreciated that the use of global translation inhibitors, such as cycloheximide, in protein degradation assays may result in artefacts, these inhibitors continue to be employed, owing...
3.
Oh J, Hyun J, Varshavsky A
Proc Natl Acad Sci U S A
. 2017 May;
114(22):E4370-E4379.
PMID: 28515311
We found that the heat shock protein 90 (Hsp90) chaperone system of the yeast is greatly impaired in cells, which lack the NatA N-terminal acetylase (Nt-acetylase) and therefore cannot N-terminally...
4.
Chen S, Wu X, Wadas B, Oh J, Varshavsky A
Science
. 2017 Jan;
355(6323).
PMID: 28126757
Cells synthesize glucose if deprived of it, and destroy gluconeogenic enzymes upon return to glucose-replete conditions. We found that the Gid4 subunit of the ubiquitin ligase GID in the yeast...
5.
Wadas B, Borjigin J, Huang Z, Oh J, Hwang C, Varshavsky A
J Biol Chem
. 2016 Jun;
291(33):17178-96.
PMID: 27339900
Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep. N-terminal sequences of...
6.
Lee J, Oh J, Ku M, Kim J, Lee J, Kang S
FEBS Lett
. 2015 Jan;
589(4):513-20.
PMID: 25601565
Ssn6 is a crucial regulator of morphological transition and virulence in the fungal pathogen Candida albicans. Ssn6 has previously been reported to act in complex with the transcriptional repressor Tup1....
7.
Piatkov K, Oh J, Liu Y, Varshavsky A
Proc Natl Acad Sci U S A
. 2014 Feb;
111(9):E817-26.
PMID: 24550490
Calpains are Ca(2+)-dependent intracellular proteases. We show here that calpain-generated natural C-terminal fragments of proteins that include G protein-coupled receptors, transmembrane ion channels, transcriptional regulators, apoptosis controllers, kinases, and phosphatases...
8.
Kim H, Kim R, Oh J, Cho H, Varshavsky A, Hwang C
Cell
. 2013 Dec;
156(1-2):158-69.
PMID: 24361105
The Arg/N-end rule pathway targets for degradation proteins that bear specific unacetylated N-terminal residues while the Ac/N-end rule pathway targets proteins through their N(α)-terminally acetylated (Nt-acetylated) residues. Here, we show...
9.
Hwang C, Oh J, Huh W, Yim H, Kang S
Mol Microbiol
. 2003 Feb;
47(4):1029-43.
PMID: 12581357
Candida albicans, the major fungal pathogen in humans, undergoes morphological conversion from yeasts to filamentous growth forms depending upon various environmental conditions. Here, we have identified a C. albicans gene,...
10.
Hwang C, Rhie G, Oh J, Huh W, Yim H, Kang S
Microbiology (Reading)
. 2002 Nov;
148(Pt 11):3705-3713.
PMID: 12427960
Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is suspected to be one of the anti-oxidant enzymes and virulence determinants active in some pathogenic micro-organisms. To elucidate the role of Cu/ZnSOD in...