Janez Konc
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Explore the profile of Janez Konc including associated specialties, affiliations and a list of published articles.
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65
Citations
711
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Recent Articles
11.
Konc J, Lesnik S, Skrlj B, Janezic D
J Chem Inf Model
. 2021 Jul;
61(8):4097-4107.
PMID: 34319727
We have developed a new system, ProBiS-Dock, which can be used to determine the different types of protein binding sites for small ligands. The binding sites identified this way are...
12.
Kralj S, Hodoscek M, Podobnik B, Kunej T, Bren U, Janezic D, et al.
Front Chem
. 2021 Jul;
9:705931.
PMID: 34277572
In a survey of novel interactions between an IgG1 antibody and different Fcγ receptors (FcγR), molecular dynamics simulations were performed of interactions of monoclonal antibody involved complexes with FcγRs. Free...
13.
Kores K, Konc J, Bren U
Pharmaceutics
. 2021 Mar;
13(3).
PMID: 33670968
Thiazolidinediones form drugs that treat insulin resistance in type 2 diabetes mellitus. Troglitazone represents the first drug from this family, which was removed from use by the FDA due to...
14.
Skrlj B, Erzen N, Lavrac N, Kunej T, Konc J
Bioinformatics
. 2020 Sep;
37(6):885-887.
PMID: 32871004
Motivation: Causal biological interaction networks represent cellular regulatory pathways. Their fusion with other biological data enables insights into disease mechanisms and novel opportunities for drug discovery. Results: We developed Causal...
15.
Jukic M, Konc J, Janezic D, Bren U
ACS Med Chem Lett
. 2020 May;
11(5):877-882.
PMID: 32435399
The ProBiS H2O MD approach for identification of conserved waters and water sites of interest in macromolecular systems, which is becoming a typical step in a structure-based drug design or...
16.
Lesnik S, Hodoscek M, Podobnik B, Konc J
J Chem Inf Model
. 2020 May;
60(11):5475-5486.
PMID: 32379970
Reduction of the affinity of the fragment crystallizable (Fc) region with immune receptors by substitution of one or a few amino acids, known as Fc-silencing, is an established approach to...
17.
Fine J, Konc J, Samudrala R, Chopra G
J Chem Inf Model
. 2020 Feb;
60(3):1509-1527.
PMID: 32069042
Small-molecule docking has proven to be invaluable for drug design and discovery. However, existing docking methods have several limitations such as improper treatment of the interactions of essential components in...
18.
Knez D, Colettis N, Iacovino L, Sova M, Pislar A, Konc J, et al.
J Med Chem
. 2020 Jan;
63(3):1361-1387.
PMID: 31917923
The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into...
19.
Lesnik S, Konc J
Methods Mol Biol
. 2019 Nov;
2089:1-28.
PMID: 31773644
Computational methods that predict and evaluate binding of ligands to receptors implicated in different pathologies have become crucial in modern drug design and discovery. Here, we describe protocols for using...
20.
Habic A, Mattick J, Calin G, Krese R, Konc J, Kunej T
OMICS
. 2019 Nov;
23(11):549-559.
PMID: 31689173
Ultraconserved elements (UCEs) are among the most popular DNA markers for phylogenomic analysis. In at least three of five placental mammalian genomes (human, dog, cow, mouse, and rat), 2189 UCEs...