Janet S Sinsheimer
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Explore the profile of Janet S Sinsheimer including associated specialties, affiliations and a list of published articles.
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156
Citations
3381
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Recent Articles
1.
Mulvihill J, Findley L, Ni W, Sinsheimer J, Cole F, Esteves C, et al.
Genet Med
. 2024 Jul;
26(10):101203.
PMID: 38967101
Purpose: Can certain characteristics identify as solvable some undiagnosed patients who seek extensive evaluation and thorough record review, such as by the Undiagnosed Diseases Network (UDN)? Methods: The UDN is...
2.
vonHoldt B, DeCandia A, Cassidy K, Stahler E, Sinsheimer J, Smith D, et al.
J Hered
. 2023 Oct;
115(4):327-338.
PMID: 37793153
For species of management concern, accurate estimates of inbreeding and associated consequences on reproduction are crucial for predicting their future viability. However, few studies have partitioned this aspect of genetic...
3.
Garske K, Kar A, Comenho C, Balliu B, Pan D, Bhagat Y, et al.
Nat Commun
. 2023 Jul;
14(1):4214.
PMID: 37452040
Obesity-induced adipose tissue dysfunction can cause low-grade inflammation and downstream obesity comorbidities. Although preadipocytes may contribute to this pro-inflammatory environment, the underlying mechanisms are unclear. We used human primary preadipocytes...
4.
Darci-Maher N, Alvarez M, Arasu U, Selvarajan I, Lee S, Pan D, et al.
EBioMedicine
. 2023 May;
92:104620.
PMID: 37224770
Background: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ectopic fat accumulation...
5.
Chu B, Ko S, Zhou J, Jensen A, Zhou H, Sinsheimer J, et al.
Bioinformatics
. 2023 Apr;
39(4).
PMID: 37067496
Motivation: In a genome-wide association study, analyzing multiple correlated traits simultaneously is potentially superior to analyzing the traits one by one. Standard methods for multivariate genome-wide association study operate marker-by-marker...
6.
Kusters C, Paul K, Romero T, Sinsheimer J, Ritz B
Alzheimers Dement
. 2023 Mar;
19(9):3826-3834.
PMID: 36938850
Introduction: Increased levels of sex hormones have been hypothesized to decrease Alzheimer's disease (AD) risk. We assessed the association between sex steroid hormones with AD using a Mendelian randomization (MR)...
7.
Paul K, Kusters C, Furlong M, Zhang K, Yu Y, Folle A, et al.
Brain Behav Immun Health
. 2022 Nov;
26:100530.
PMID: 36325427
Although Parkinson's Disease (PD) is typically described in terms of motor symptoms, depression is a common feature. We explored whether depression influences blood-based genome-wide DNA methylation (DNAm) in 692 subjects...
8.
Alvarez M, Benhammou J, Darci-Maher N, French S, Han S, Sinsheimer J, et al.
Genome Med
. 2022 May;
14(1):50.
PMID: 35581624
Background: Hepatocellular carcinoma (HCC) is a common primary liver cancer with poor overall survival. We hypothesized that there are HCC-associated cell-types that impact patient survival. Methods: We combined liver single...
9.
Kusters C, Paul K, Folle A, Keener A, Bronstein J, Bertram L, et al.
Mov Disord
. 2022 Mar;
37(6):1282-1283.
PMID: 35245402
No abstract available.
10.
Ko S, German C, Jensen A, Shen J, Wang A, Mehrotra D, et al.
Am J Hum Genet
. 2022 Feb;
109(3):433-445.
PMID: 35196515
Biobanks linked to massive, longitudinal electronic health record (EHR) data make numerous new genetic research questions feasible. One among these is the study of biomarker trajectories. For example, high blood...