Janet Dawson
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Explore the profile of Janet Dawson including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
746
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0
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Recent Articles
1.
Velcicky J, Janser P, Gommermann N, Brenneisen S, Ilic S, Vangrevelinghe E, et al.
J Med Chem
. 2024 Jan;
67(2):1544-1562.
PMID: 38175811
NLRP3 is a molecular sensor recognizing a wide range of danger signals. Its activation leads to the assembly of an inflammasome that allows for activation of caspase-1 and subsequent maturation...
2.
Hoyler T, Bannert B, Andre C, Beck D, Boulay T, Buffet D, et al.
JCI Insight
. 2022 Jul;
7(13).
PMID: 35801586
IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic inflammatory diseases is underappreciated. To...
3.
Accart N, Dawson J, Obrecht M, Lambert C, Flueckiger M, Kreider J, et al.
Sci Rep
. 2022 Jan;
12(1):157.
PMID: 34997110
The objective of this work was to assess the consequences of repeated intra-articular injection of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) in order to simulate recurrent...
4.
Dawson J, Vogelsanger M
Curr Protoc
. 2021 Feb;
1(2):e49.
PMID: 33600079
The cantharidin-induced skin blister is a simple model for investigating cell migration and inflammatory mediator production at a site of inflammation. Application of cantharidin solution to the ear pinna results...
5.
Markert C, Thoma G, Srinivas H, Bollbuck B, Luond R, Miltz W, et al.
J Med Chem
. 2021 Feb;
64(4):1889-1903.
PMID: 33592148
The cytosolic metalloenzyme leukotriene A hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B (LTB). Preclinical studies have validated this enzyme as an attractive...
6.
Spieler V, Ludwig M, Dawson J, Tigani B, Littlewood-Evans A, Safina C, et al.
J Control Release
. 2020 Jul;
326:172-180.
PMID: 32653504
Anti-inflammatory cytokines are a promising class of therapeutics for treatment of rheumatoid arthritis (RA), but their use is currently limited by a rapid clearance and systemic toxicity. Interleukin-4 is a...
7.
Angst D, Gessier F, Janser P, Vulpetti A, Walchli R, Beerli C, et al.
J Med Chem
. 2020 Feb;
63(10):5102-5118.
PMID: 32083858
Bruton's tyrosine kinase (BTK), a cytoplasmic tyrosine kinase, plays a central role in immunity and is considered an attractive target for treating autoimmune diseases. The use of currently marketed covalent...
8.
Hoegenauer K, Kallen J, Jimenez-Nunez E, Strang R, Ertl P, Cooke N, et al.
J Med Chem
. 2019 Nov;
62(23):10816-10832.
PMID: 31729873
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) is considered to be the master transcription factor for the development of Th17 cells that produce proinflammatory cytokines such as IL-17A. Overproportionate Th17...
9.
Pulz R, Angst D, Dawson J, Gessier F, Gutmann S, Hersperger R, et al.
ACS Med Chem Lett
. 2019 Oct;
10(10):1467-1472.
PMID: 31620235
Bruton's tyrosine kinase (BTK) is a member of the TEC kinase family and is selectively expressed in a subset of immune cells. It is a key regulator of antigen receptor...
10.
Carcache D, Vulpetti A, Kallen J, Mattes H, Orain D, Stringer R, et al.
J Med Chem
. 2018 Jul;
61(15):6724-6735.
PMID: 29990434
The transcription factor RORγt is an attractive drug-target due to its role in the differentiation of IL-17 producing Th17 cells that play a critical role in the etiopathology of several...