Janeesh Plakkal Ayyappan
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Explore the profile of Janeesh Plakkal Ayyappan including associated specialties, affiliations and a list of published articles.
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14
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139
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Recent Articles
1.
Chandran M, Rameshkumar K, Jaleel A, Ayyappan J
Chem Biol Drug Des
. 2025 Feb;
105(2):e70055.
PMID: 39902651
Cardiovascular diseases (CVDs) continue to be one of the leading causes of morbidity and mortality worldwide, with a significant increase in recent years. Atherosclerosis, the pathological basis and prime reason...
2.
Abhirami N, Ayyappan J
Cell Biochem Biophys
. 2024 Aug;
82(4):3681-3694.
PMID: 39095567
Robinin is one of the glycosyloxyflavones that has been less explored for its therapeutic application, especially in the field of CVD. Herein, we explored the cardioprotective efficacy of Robinin by...
3.
Goo Y, Ayyappan J, Cheeran F, Bangru S, Saha P, Baar P, et al.
Nat Commun
. 2024 Aug;
15(1):6540.
PMID: 39095402
Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood. LD-associated hydrolase (LDAH) has a lipase structure and high...
4.
Sufina Nazar S, Ayyappan J
J Biochem Mol Toxicol
. 2024 May;
38(6):e23740.
PMID: 38779996
The current study was focused on the anticancer activity of myristicin against MCF-7 human breast cancer (BC) cells. BC is the most common and leading malignant disease in women worldwide....
5.
Abhirami N, Chandran M, Ramadasan A, Bhasura D, Ayyappan J
Fundam Clin Pharmacol
. 2023 Nov;
38(2):276-289.
PMID: 37990640
Background: Myocardial infarction poses major risks to human health because of their incredibly high rates of morbidity and mortality. Infarctions are more likely to develop as a result of dysregulation...
6.
Chandran M, S S, Abhirami , Chandran A, Jaleel A, Ayyappan J
Mol Omics
. 2022 Nov;
19(1):6-26.
PMID: 36426765
Atherosclerosis is the principal cause of vascular diseases and one of the leading causes of worldwide death. Even though several insights into its natural course, risk factors and interventions have...
7.
Ayyappan J, Lizardo K, Wang S, Yurkow E, Nagajyothi J
J Am Heart Assoc
. 2020 Jan;
9(3):e014255.
PMID: 31973605
Background is an intracellular parasite that causes debilitating chronic Chagas cardiomyopathy (CCM), for which there is no effective drug or vaccine. Previously, we demonstrated increased cardiac lipid accumulation and endoplasmic...
8.
Lizardo K, Ayyappan J, Ganapathi U, Dutra W, Qiu Y, Weiss L, et al.
Dis Markers
. 2020 Jan;
2019:4956016.
PMID: 31949545
Chagas disease is caused by which is endemic in Latin America. infection results in a latent infection with approximately a third of latently infected patients developing chronic Chagas cardiomyopathy (CCM)....
9.
Ayyappan J, Ganapathi U, Lizardo K, Vinnard C, Subbian S, Perlin D, et al.
mBio
. 2019 Apr;
10(2).
PMID: 30992360
Tuberculosis (TB), caused by infection, remains a major cause of mortality and morbidity worldwide. One-third of the world population is infected with , and about 15 million people with latent...
10.
Ayyappan J, Lizardo K, Wang S, Yurkow E, Nagajyothi J
Biomol Ther (Seoul)
. 2019 Mar;
27(4):386-394.
PMID: 30879276
infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM) has been...