Jan Zarzycki
Overview
Explore the profile of Jan Zarzycki including associated specialties, affiliations and a list of published articles.
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39
Citations
1230
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Recent Articles
1.
Schulz L, Zarzycki J, Steinchen W, Hochberg G, Erb T
EMBO J
. 2024 Nov;
44(1):269-280.
PMID: 39558108
Protein complexes composed of strictly essential subunits are abundant in nature and often arise through the gradual complexification of ancestral precursor proteins. Essentiality can arise through the accumulation of changes...
2.
He H, Gomez-Coronado P, Zarzycki J, Barthel S, Kahnt J, Claus P, et al.
Nat Commun
. 2024 Oct;
15(1):8898.
PMID: 39406738
Promiscuous enzymes often serve as the starting point for the evolution of novel functions. Yet, the extent to which the promiscuity of an individual enzyme can be harnessed several times...
3.
Schmidt F, Schulz L, Zarzycki J, Prinz S, Oehlmann N, Erb T, et al.
Nat Struct Mol Biol
. 2023 Dec;
31(1):150-158.
PMID: 38062208
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently, nitrogenases were shown to reduce carbon dioxide (CO) and carbon monoxide to...
4.
Marchal D, Schulz L, Schuster I, Ivanovska J, Paczia N, Prinz S, et al.
ACS Synth Biol
. 2023 Nov;
12(12):3521-3530.
PMID: 37983631
Glycolyl-CoA carboxylase (GCC) is a new-to-nature enzyme that catalyzes the key reaction in the tartronyl-CoA (TaCo) pathway, a synthetic photorespiration bypass that was recently designed to improve photosynthetic CO fixation....
5.
Kremer K, Meier D, Theis L, Miller S, Rost-Nasshan A, Naing Y, et al.
Appl Environ Microbiol
. 2023 Jun;
89(7):e0023823.
PMID: 37318336
Metabolic degeneracy describes the phenomenon that cells can use one substrate through different metabolic routes, while metabolic plasticity, refers to the ability of an organism to dynamically rewire its metabolism...
6.
McLean R, Schwander T, Diehl C, Cortina N, Paczia N, Zarzycki J, et al.
Sci Adv
. 2023 Jun;
9(24):eadh4299.
PMID: 37315145
Nature has evolved eight different pathways for the capture and conversion of CO, including the Calvin-Benson-Bassham cycle of photosynthesis. Yet, these pathways underlie constrains and only represent a fraction of...
7.
Nattermann M, Wenk S, Pfister P, He H, Lee S, Szymanski W, et al.
Nat Commun
. 2023 May;
14(1):2682.
PMID: 37160875
Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced from CO by (electro-)chemical means and converted into value-added products by enzymatic cascades or engineered...
8.
Pfister P, Zarzycki J, Erb T
Biochemistry
. 2022 Dec;
62(1):75-84.
PMID: 36535006
Mesaconyl-CoA transferase (Mct) is one of the key enzymes of the 3-hydroxypropionate (3HP) bi-cycle for autotrophic CO fixation. Mct is a family III/Frc family CoA transferase that catalyzes an unprecedented...
9.
Schulz L, Guo Z, Zarzycki J, Steinchen W, Schuller J, Heimerl T, et al.
Science
. 2022 Oct;
378(6616):155-160.
PMID: 36227987
The evolution of ribulose-1,5-bisphosphate carboxylase/oxygenases (Rubiscos) that discriminate strongly between their substrate carbon dioxide and the undesired side substrate dioxygen was an important event for photosynthetic organisms adapting to an...
10.
Nattermann M, Burgener S, Pfister P, Chou A, Schulz L, Lee S, et al.
ACS Catal
. 2021 Sep;
11(9):5396-5404.
PMID: 34484855
One of the biggest challenges to realize a circular carbon economy is the synthesis of complex carbon compounds from one-carbon (C1) building blocks. Since the natural solution space of C1-C1...