Jan Van Bocxlaer
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Explore the profile of Jan Van Bocxlaer including associated specialties, affiliations and a list of published articles.
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Citations
526
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Recent Articles
11.
Xie F, Van Bocxlaer J, Colin P, Carlier C, Van Kerschaver O, Weerts J, et al.
AAPS J
. 2020 Jul;
22(5):96.
PMID: 32710204
Intraperitoneal chemoperfusion (IPEC) of cisplatin is a popular treatment for advanced ovarian cancer, typically under hyperthermia (HIPEC). The use of cisplatin under (H)IPEC is off-label, and the role of hyperthermia...
12.
Xie F, Van Bocxlaer J, Vermeulen A
Br J Clin Pharmacol
. 2020 Jul;
87(3):1203-1214.
PMID: 32693432
Aims: Lisinopril is an angiotensin converting enzyme inhibitor to treat hypertension. It shows complex pharmacokinetics (PK), and its PK behaviour in paediatric populations is not well characterized. The aim of...
13.
Gasthuys E, Dossche L, Michelet R, Norgaard J, Devreese M, Croubels S, et al.
Paediatr Drugs
. 2020 Jun;
22(4):369-383.
PMID: 32507959
Desmopressin is a synthetic analogue of the natural antidiuretic hormone arginine vasopressin. Over the years, it has been clinically used to manage nocturnal polyuria in children with enuresis. Various pharmaceutical...
14.
De Thaye E, Van de Vijver K, Van der Meulen J, Taminau J, Wagemans G, Denys H, et al.
Sci Rep
. 2020 Apr;
10(1):6688.
PMID: 32317693
Peritoneal spread indicates poor prognosis in patients with serous ovarian carcinoma (SOC) and is generally treated by surgical cytoreduction and chemotherapy. Novel treatment options are urgently needed to improve patient...
15.
Jonckheere S, De Neve N, Verbeke J, De Decker K, Brandt I, Boel A, et al.
Antimicrob Agents Chemother
. 2019 Nov;
64(1).
PMID: 31685467
Attainment of appropriate pharmacokinetic-pharmacodynamic (PK-PD) targets for antimicrobial treatment is challenging in critically ill patients, particularly for cefepime, which exhibits a relative narrow therapeutic-toxic window compared to other beta-lactam antibiotics....
16.
Michelet R, Dossche L, Van Herzeele C, De Bruyne P, Gasthuys E, Van Bocxlaer J, et al.
Clin Pharmacokinet
. 2019 Jul;
59(1):81-96.
PMID: 31347012
Introduction: The bioequivalence of two formulations of desmopressin (dDAVP), a vasopressin analogue prescribed for nocturnal enuresis treatment in children, has been previously confirmed in adults but not in children. In...
17.
Schelstraete W, De Clerck L, Govaert E, Millecam J, Devreese M, Deforce D, et al.
Sci Rep
. 2019 Jun;
9(1):9233.
PMID: 31239454
Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in...
18.
Xie F, De Clercq K, Vervaet C, Van Bocxlaer J, Colin P, Vermeulen A
Pharm Res
. 2019 Jun;
36(9):127.
PMID: 31236836
Purpose: Paclitaxel (PTX)-loaded genipin-crosslinked gelatin microspheres (GP-MS) are a prolonged IP delivery system under development for the treatment of peritoneal minimal residual disease (pMRD). Here, we show the use of...
19.
van Lancker G, van Bortel L, Delafontaine B, Boussery K, Swart E, Chahbouni A, et al.
Clin Pharmacol Ther
. 2019 Jan;
106(1):195-203.
PMID: 30636281
Generic substitution of antiepileptic drugs is generally not advised by neurologists. The present study investigated the switchability of gabapentin 800 mg tablets (Neurontin and Gabasandoz) using an individual bioequivalence (IBE)...
20.
Xie F, Mantzarlis K, Malliotakis P, Koulouras V, Degroote S, Koulenti D, et al.
J Antimicrob Chemother
. 2018 Dec;
74(3):667-674.
PMID: 30535122
Objectives: Altered linezolid pharmacokinetics (PK) in obese individuals has been hypothesized in previous studies. However, specific dosing recommendations for this population are still lacking. The main goal of this study...