Jan Stout
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Explore the profile of Jan Stout including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
86
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Recent Articles
1.
Tiels P, Baranova E, Piens K, De Visscher C, Pynaert G, Nerinckx W, et al.
Nat Biotechnol
. 2012 Nov;
30(12):1225-31.
PMID: 23159880
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the...
2.
Stout J, De Vos D, Vergauwen B, Savvides S
J Mol Biol
. 2012 Jan;
416(4):486-94.
PMID: 22226834
Glutathione is an intracellular redox-active tripeptide thiol with a central role in cellular physiology across all kingdoms of life. Glutathione biosynthesis has been traditionally viewed as a conserved process relying...
3.
de Groeve M, Remmery L, Van Hoorebeke A, Stout J, Desmet T, Savvides S, et al.
Biotechnol Bioeng
. 2010 Jun;
107(3):413-20.
PMID: 20517986
The general application of glycoside phosphorylases such as cellobiose phosphorylase (CP) for glycoside synthesis is hindered by their relatively narrow substrate specificity. We have previously reported on the creation of...
4.
Van Hoorebeke A, Stout J, Van der Meeren R, Kyndt J, Van Beeumen J, Savvides S
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Apr;
66(Pt 4):442-7.
PMID: 20383018
Disaccharide phosphorylases are attractive enzymatic platforms for tailor-made sugar synthesis owing to their ability to catalyze both the synthesis and the breakdown of disaccharides. Trehalose phosphorylase from Thermoanaerobacter sp. (TP)...
5.
Van Hoorebeke A, Stout J, Kyndt J, De Groeve M, Dix I, Desmet T, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Mar;
66(Pt 3):346-51.
PMID: 20208178
Disaccharide phosphorylases are able to catalyze both the synthesis and the breakdown of disaccharides and have thus emerged as attractive platforms for tailor-made sugar synthesis. Cellobiose phosphorylase from Cellulomonas uda...
6.
Elegheert J, van den Hemel D, Dix I, Stout J, Van Beeumen J, Brige A, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Jan;
66(Pt 1):85-90.
PMID: 20057079
Shewanella oneidensis is an environmentally versatile Gram-negative gamma-proteobacterium that is endowed with an unusually large proteome of redox proteins. Of the four old yellow enzyme (OYE) homologues found in S....
7.
Remmerie B, Vandenbroucke K, Smet L, Carpentier W, De Vos D, Stout J, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2008 Jun;
64(Pt 6):548-53.
PMID: 18540073
Genome analysis of Shewanella oneidensis, a Gram-negative bacterium with an unusual repertoire of respiratory and redox capabilities, revealed the presence of six glutathione S-transferase-like genes (sogst1-sogst6). Glutathione S-transferases (GSTs; EC...
8.
Stout J, Van Driessche G, Savvides S, Van Beeumen J
Protein Sci
. 2007 Mar;
16(4):589-601.
PMID: 17327392
Dissimilatory oxidation of thiosulfate in the green sulfur bacterium Chlorobium limicola f. thiosulfatophilum is carried out by the ubiquitous sulfur-oxidizing (Sox) multi-enzyme system. In this system, SoxY plays a key...
9.
Stout J, Smet L, Panjikar S, Weiss M, Savvides S, Van Beeumen J
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2006 Nov;
62(Pt 11):1093-6.
PMID: 17077486
The 22 kDa SoxYZ protein complex from the green sulfur bacterium Chlorobium limicola f. thiosulfatophilum is a central player in the sulfur-oxidizing (Sox) enzyme system of the organism by activating...