Jan Stephan Bolten
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Explore the profile of Jan Stephan Bolten including associated specialties, affiliations and a list of published articles.
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9
Citations
40
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Recent Articles
1.
Alter C, Lotter C, Puligilla R, Bolten J, Sedzicki J, Marchese J, et al.
Adv Healthc Mater
. 2024 Nov;
14(1):e2401888.
PMID: 39523736
Lipid nanoparticles (LNPs) have emerged as the leading nonviral nucleic acid (NA) delivery system, gaining widespread attention for their use in COVID-19 vaccines. They are recognized for their efficient NA...
2.
Oezen G, Kraus L, Schentarra E, Bolten J, Huwyler J, Fricker G
Environ Toxicol Pharmacol
. 2024 Apr;
108:104451.
PMID: 38648870
Aluminum is the third most common element on Earth´s crust and despite its wide use in our workaday life it has been associated with several health risks after overexposure. In...
3.
Bolten J, Tanner C, Rodgers G, Schulz G, Levano S, Weitkamp T, et al.
PLoS One
. 2023 Apr;
18(4):e0284562.
PMID: 37079551
Nephrotoxicity is an important drug safety aspect to be assessed during drug discovery and development. To study renal toxicity, in vitro cell-based assays are often used. Unfortunately, translating the results...
4.
Bolten J, Mancuso R, Roos N, Mayr A, Puligilla R, Kraus L, et al.
Toxicol Appl Pharmacol
. 2023 Mar;
466:116493.
PMID: 36977437
Iopamidol is a nonionic, low-osmolar iodinated contrast agent used for angiography. Its clinical use is associated with renal dysfunction. Patients suffering from preexisting kidney disease have an increased risk of...
5.
Oezen G, Schentarra E, Bolten J, Huwyler J, Fricker G
Aquat Toxicol
. 2022 Oct;
252:106314.
PMID: 36201872
ABC export proteins including Multidrug resistance-related protein 2 (Mrp2) serve as detoxification mechanism in renal proximal tubules due to active transport of xenobiotics and metabolic waste products into primary urine....
6.
Jooss V, Bolten J, Huwyler J, Ahmed D
Sci Adv
. 2022 Mar;
8(12):eabm2785.
PMID: 35333569
In vivo micromanipulation using ultrasound is an exciting technology with promises for cancer research, brain research, vasculature biology, diseases, and treatment development. In the present work, we demonstrate in vivo...
7.
Lotter C, Alter C, Bolten J, Detampel P, Palivan C, Einfalt T, et al.
Eur J Pharm Biopharm
. 2022 Feb;
172:134-143.
PMID: 35181492
The essential homeostatic process of dead cell clearance (efferocytosis) is used by viruses in an act of apoptotic mimicry. Among others, virions leverage phosphatidylserine (PS) as an essential "eat me"...
8.
Bolten J, Pratsinis A, Alter C, Fricker G, Huwyler J
Am J Physiol Renal Physiol
. 2022 Jan;
322(3):F280-F294.
PMID: 35037468
There is an increasing interest in using zebrafish () larva as a vertebrate screening model to study drug disposition. As the pronephric kidney of zebrafish larvae shares high similarity with...
9.
Pratsinis A, Uhl P, Bolten J, Hauswirth P, Schenk S, Urban S, et al.
Mol Pharm
. 2021 Apr;
18(5):2004-2014.
PMID: 33844553
Recently, a lipopeptide derived from the hepatitis B virus (HBV) large surface protein has been developed as an HBV entry inhibitor. This lipopeptide, called MyrcludexB (MyrB), selectively binds to the...