Jan Motlik
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Explore the profile of Jan Motlik including associated specialties, affiliations and a list of published articles.
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84
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1294
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Recent Articles
1.
Kiraly P, Klein J, Seitz I, Reichel F, Peters T, Ardan T, et al.
Invest Ophthalmol Vis Sci
. 2025 Jan;
66(1):48.
PMID: 39836403
Purpose: This study aimed to evaluate early-phase safety of subretinal application of AAVanc80.CAG.USH1Ca1 (OT_USH_101) in wild-type (WT) pigs, examining the effects of a vehicle control, low dose, and high dose....
2.
Seitz I, Peters T, Reichel F, Bahr A, Auch H, Motlik J, et al.
Invest Ophthalmol Vis Sci
. 2024 Oct;
65(12):41.
PMID: 39466231
Purpose: Subretinal (SR) injection in porcine models is a promising avenue for preclinical evaluation of cell and gene therapies. Targeting of the subretinal fluid compartment (bleb) is critical to the...
3.
Stranak Z, Ardan T, Nemesh Y, Toms M, Toualbi L, Harbottle R, et al.
Curr Eye Res
. 2024 Apr;
49(8):879-887.
PMID: 38666493
Purpose: To assess the safety and feasibility of direct vitrectomy-sparing subretinal injection for gene delivery in a large animal model. Methods: The experimental Liběchov minipigs were used for subretinal delivery...
4.
Gupta S, Lytvynchuk L, Ardan T, Studenovska H, Sharma R, Faura G, et al.
Stem Cells Transl Med
. 2023 Jul;
12(8):536-552.
PMID: 37459045
Retinal pigment epithelium (RPE) is a critical cell monolayer forming the blood-retina-barrier (BRB) and a permeable bridge between the choriocapillaris and the retina. RPE is also crucial in maintaining photoreceptor...
5.
Wimmer T, Sawinski H, Urban A, Motlik J, Stieger K
Nucleic Acid Ther
. 2023 Mar;
33(3):226-232.
PMID: 36857739
Stargardt disease (STGD) leads to blindness in children and young adults. So far, no curative therapy is available and gene augmentation therapies have not yet advanced to the clinics, in...
6.
Gupta S, Lytvynchuk L, Ardan T, Studenovska H, Faura G, Eide L, et al.
Biomedicines
. 2023 Feb;
11(2).
PMID: 36830851
The retinal pigment epithelium (RPE) forms an important cellular monolayer, which contributes to the normal physiology of the eye. Damage to the RPE leads to the development of degenerative diseases,...
7.
Lytvynchuk L, Stranak Z, Studenovska H, Rais D, Popelka S, Tichotova L, et al.
J Vis Exp
. 2022 Nov;
(189).
PMID: 36440839
Degenerative disorders of the retina (including age-related macular degeneration), which originate primarily at or within the retinal pigmented epithelial (RPE) layer, lead to a progressive disorganization of the retinal anatomy...
8.
Pasak M, Vanisova M, Tichotova L, Krizova J, Ardan T, Nemesh Y, et al.
Biomolecules
. 2022 Oct;
12(10).
PMID: 36291741
Retinal ischemia (RI) and progressive neuronal death are sight-threatening conditions. Mitochondrial (mt) dysfunction and fusion/fission processes have been suggested to play a role in the pathophysiology of RI. This study...
9.
Tadokoro T, Bravo-Hernandez M, Agashkov K, Kobayashi Y, Platoshyn O, Navarro M, et al.
Mol Ther
. 2022 May;
30(8):2722-2745.
PMID: 35524407
Second-order spinal cord excitatory neurons play a key role in spinal processing and transmission of pain signals to the brain. Exogenously induced change in developmentally imprinted excitatory neurotransmitter phenotypes of...
10.
Lytvynchuk L, Ebbert A, Studenovska H, Nagymihaly R, Josifovska N, Rais D, et al.
Biomedicines
. 2022 Mar;
10(3).
PMID: 35327471
Purpose: The development of primary human retinal pigmented epithelium (hRPE) for clinical transplantation purposes on biodegradable scaffolds is indispensable. We hereby report the results of the subretinal implantation of hRPE...