Jan M Deussing
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Explore the profile of Jan M Deussing including associated specialties, affiliations and a list of published articles.
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3339
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Recent Articles
1.
van Doeselaar L, Abromeit A, Stark T, Menegaz D, Ballmann M, Mitra S, et al.
Nat Commun
. 2025 Mar;
16(1):2529.
PMID: 40087272
Early life stress (ELS) can increase vulnerability to psychiatric disorders, but also trigger resilience. FKBP51 has been associated with an increased risk for developing psychiatric disorders, specifically in interaction with...
2.
von Mucke-Heim I, Oldekamp J, Metzger M, Klaffgen S, Tang H, Walser S, et al.
Purinergic Signal
. 2025 Mar;
PMID: 40024982
The P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel expressed in different cell types of the brain. Polymorphisms in the P2RX7 gene have repeatedly been associated with psychiatric disorders...
3.
Kovarova V, Bordes J, Mitra S, Narayan S, Springer M, Brix L, et al.
Neuropsychopharmacology
. 2024 Oct;
50(3):556-567.
PMID: 39438757
The co-chaperone FKBP51, encoded by FKBP5 gene, is recognized as a psychiatric risk factor for anxiety and depressive disorders due to its crucial role in the stress response. Another key...
4.
Loganathan S, Menegaz D, Delling J, Eder M, Deussing J
Transl Psychiatry
. 2024 Oct;
14(1):421.
PMID: 39370418
CACNA1C, coding for the α1 subunit of L-type voltage-gated calcium channel (LTCC) Ca1.2, has been associated with multiple psychiatric disorders. Clinical studies have revealed alterations in behavior as well as...
5.
Cheng X, Ren W, Li X, Deussing J, Illes P, Tang Y, et al.
Purinergic Signal
. 2024 Sep;
PMID: 39325357
Acute stress causes depressive-like reactions in the tail suspension (TST) and forced swim tests (FST) of mice. Similarly, inescapable foot shock is able to promote the development of anhedonia as...
6.
Sen P, Ortiz O, Brivio E, Menegaz D, Sotillos Elliott L, Du Y, et al.
Mol Psychiatry
. 2024 Jul;
30(1):97-110.
PMID: 39003412
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has previously been associated with bipolar disorder (BD). Here...
7.
Giusti S, Pino N, Pannunzio C, Ogando M, Armando N, Garrett L, et al.
Sci Adv
. 2024 May;
10(21):eadj8769.
PMID: 38787942
Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains unexplored, partly because of...
8.
Stepan J, Heinz D, Dethloff F, Wiechmann S, Martinelli S, Hafner K, et al.
Sci Signal
. 2024 Apr;
17(834):eadj6603.
PMID: 38687825
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate for learning and memory. The Hippo pathway member WWC1 is an...
9.
DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans
Yusupov N, Roeh S, Sotillos Elliott L, Chang S, Loganathan S, Urbina-Trevino L, et al.
Mol Psychiatry
. 2024 Feb;
29(5):1510-1520.
PMID: 38317011
Humanized mouse models can be used to explore human gene regulatory elements (REs), which frequently lie in non-coding and less conserved genomic regions. Epigenetic modifications of gene REs, also in...
10.
von Mucke-Heim I, Pape J, Grandi N, Erhardt A, Deussing J, Binder E
Eur Arch Psychiatry Clin Neurosci
. 2023 Aug;
274(3):673-684.
PMID: 37644215
Electroconvulsive therapy (ECT) is commonly used to treat treatment-resistant depression (TRD). However, our knowledge of the ECT-induced molecular mechanisms causing clinical improvement is limited. To address this issue, we developed...