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Jan G Christian

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Articles 5
Citations 124
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Recent Articles
1.
Isnard A, Christian J, Kodiha M, Stochaj U, McMaster W, Olivier M
PLoS Pathog . 2015 Apr; 11(3):e1004776. PMID: 25826301
The protease GP63 is an important virulence factor of Leishmania parasites. We previously showed that GP63 reaches the perinuclear area of host macrophages and that it directly modifies nuclear translocation...
2.
Christian J, Heymann J, Paschen S, Vier J, Schauenburg L, Rupp J, et al.
PLoS Pathog . 2011 Oct; 7(9):e1002283. PMID: 21990969
Chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministacks, which...
3.
Haider S, Wagner M, Schmid M, Sixt B, Christian J, Hacker G, et al.
Mol Microbiol . 2010 Jun; 77(3):687-700. PMID: 20545842
The phylum Chlamydiae consists exclusively of obligate intracellular bacteria. Some of them are formidable pathogens of humans, while others occur as symbionts of amoebae. These genetically intractable bacteria possess a...
4.
Paschen S, Christian J, Vier J, Schmidt F, Walch A, Ojcius D, et al.
J Cell Biol . 2008 Jul; 182(1):117-27. PMID: 18625845
Chlamydiae replicate in a vacuole within epithelial cells and commonly induce cell damage and a deleterious inflammatory response of unknown molecular pathogenesis. The chlamydial protease-like activity factor (CPAF) translocates from...
5.
Ying S, Christian J, Paschen S, Hacker G
Microbes Infect . 2007 Dec; 10(1):97-101. PMID: 18069034
Infection with Chlamydia protects mammalian host cells against apoptosis. Hypotheses have been proposed to explain this molecularly, including the up-regulation of host anti-apoptotic proteins such as cellular Inhibitor of Apoptosis...