Jan Broder Engler
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Explore the profile of Jan Broder Engler including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Walkenhorst M, Sonner J, Meurs N, Engler J, Bauer S, Winschel I, et al.
Nat Commun
. 2024 Oct;
15(1):9287.
PMID: 39468055
Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1...
2.
Woo M, Engler J, Friese M
Nat Rev Neurosci
. 2024 May;
25(7):493-513.
PMID: 38789516
Chronic low-grade inflammation and neuronal deregulation are two components of a smoldering disease activity that drives the progression of disability in people with multiple sclerosis (MS). Although several therapies exist...
3.
Winschel I, Willing A, Engler J, Walkenhorst M, Meurs N, Binkle-Ladisch L, et al.
Biol Sex Differ
. 2024 May;
15(1):41.
PMID: 38750588
Background: Differences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune diseases that predominantly affect women, such as multiple sclerosis...
4.
Winkler I, Engler J, Vieira V, Bauer S, Liu Y, Di Liberto G, et al.
Sci Adv
. 2023 Nov;
9(47):eadi6855.
PMID: 38000031
Neuroinflammation causes neuronal injury in multiple sclerosis (MS) and other neurological diseases. MicroRNAs (miRNAs) are important modulators of neuronal stress responses, but knowledge about their contribution to neuronal protection or...
5.
Woo M, Ufer F, Sonner J, Belkacemi A, Tintelnot J, Saez P, et al.
Sci Adv
. 2023 Sep;
9(38):eadh1653.
PMID: 37729408
Migratory dendritic cells (migDCs) continuously patrol tissues and are activated by injury and inflammation. Extracellular adenosine triphosphate (ATP) is released by damaged cells or actively secreted during inflammation and increases...
6.
Krieg P, Sonner J, Kurelic R, Engler J, Scharenberg M, Bauer S, et al.
Front Immunol
. 2023 Feb;
13:1113348.
PMID: 36761164
G-protein coupled receptors (GPCR) regulate 3',5'-cyclic adenosine monophosphate (cAMP) levels in T cells. cAMP as ubiquitous second messenger is crucial for adequate physiology of T cells by mediating effector T...
7.
Rothammer N, Woo M, Bauer S, Binkle-Ladisch L, Di Liberto G, Egervari K, et al.
Sci Adv
. 2022 Aug;
8(31):eabm5500.
PMID: 35930635
Neuroinflammation leads to neuronal stress responses that contribute to neuronal dysfunction and loss. However, treatments that stabilize neurons and prevent their destruction are still lacking. Here, we identify the histone...
8.
Kaufmann M, Evans H, Schaupp A, Engler J, Kaur G, Willing A, et al.
Med
. 2021 Mar;
2(3):296-312.e8.
PMID: 33748804
Background: Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), can be suppressed in its early stages but eventually becomes clinically progressive and unresponsive to therapy. Here,...
9.
Woo M, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, et al.
J Exp Med
. 2021 Mar;
218(5).
PMID: 33661276
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with continuous neuronal loss. Treatment of clinical progression remains challenging due to lack of insights into inflammation-induced...
10.
Rosenkranz S, Shaposhnykov A, Trager S, Engler J, Witte M, Roth V, et al.
Elife
. 2021 Feb;
10.
PMID: 33565962
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function...