Jan Aelen
Overview
Explore the profile of Jan Aelen including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
179
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Recent Articles
1.
Hilge M, Aelen J, Foarce A, Perrakis A, Vuister G
Proc Natl Acad Sci U S A
. 2009 Aug;
106(34):14333-8.
PMID: 19667209
Regulation of ion-transport in the Na(+)/Ca(2+) exchanger (NCX) occurs via its cytoplasmic Ca(2+)-binding domains, CBD1 and CBD2. Here, we present a mechanism for NCX activation and inactivation based on data...
2.
Hilge M, Aelen J, Perrakis A, Vuister G
Ann N Y Acad Sci
. 2007 Mar;
1099:7-15.
PMID: 17347334
Binding of Na+ and Ca2+ ions to the large cytosolic loop of the Na+/Ca2+ exchanger (NCX) regulates its ion transport across the plasma membrane. We determined the solution structures of...
3.
Hilge M, Aelen J, Vuister G
Mol Cell
. 2006 Apr;
22(1):15-25.
PMID: 16600866
The plasma membrane Na+/Ca2+ exchanger (NCX) is almost certainly the major Ca2+ extrusion mechanism in cardiac myocytes. Binding of Na+ and Ca2+ ions to its large cytosolic loop regulates ion...
4.
Ingen H, Baltussen M, Aelen J, Vuister G
J Mol Biol
. 2006 Mar;
358(2):485-97.
PMID: 16519900
The co-repressor Sin3 is the essential scaffold protein of the Sin3/HDAC co-repressor complex, which is recruited to the DNA by a diverse group of transcriptional repressors, targeting genes involved in...
5.
van den Berk L, van Ham M, te Lindert M, Walma T, Aelen J, Vuister G, et al.
Mol Biol Rep
. 2005 Jan;
31(4):203-15.
PMID: 15663004
PDZ domains are protein-protein interaction modules that are crucial for the assembly of structural and signaling complexes. PDZ domains specifically bind short carboxyl-terminal peptides and occasionally internal sequences that structurally...
6.
Walma T, Aelen J, Nabuurs S, Oostendorp M, van den Berk L, Hendriks W, et al.
Structure
. 2004 Jan;
12(1):11-20.
PMID: 14725761
PTP-BL is a large phosphatase that is implicated in cellular processes as diverse as cytokinesis, actin-cytoskeletal rearrangement, and apoptosis. Five PDZ domains mediate its cellular role by binding to the...
7.
Walma T, Spronk C, Tessari M, Aelen J, Schepens J, Hendriks W, et al.
J Mol Biol
. 2002 Mar;
316(5):1101-10.
PMID: 11884147
The PDZ domains of the protein tyrosine phosphatase PTP-BL mediate interactions by binding to specific amino acid sequences in target proteins. The solution structure of the second PDZ domain of...