Jan-Erik Frodin
Overview
Explore the profile of Jan-Erik Frodin including associated specialties, affiliations and a list of published articles.
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40
Citations
441
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Recent Articles
11.
Sclafani F, Kim T, Cunningham D, Kim T, Tabernero J, Schmoll H, et al.
Int J Cancer
. 2016 Sep;
140(2):431-439.
PMID: 27681944
Limited data are available on the efficacy of anti-IGF-1R agents in KRAS mutant colorectal cancer (CRC). We analysed the outcome of 69 chemorefractory, KRAS exon 2 mutant CRC patients who...
12.
Lohr J, Karimi M, Omazic B, Kartalis N, Verbeke C, Berkenstam A, et al.
Pancreatology
. 2016 May;
16(4):640-5.
PMID: 27234064
Background: AXP107-11 is a novel, multi-component crystalline form of the naturally occurring compound genistein. AXP107-11 has improved physiochemical properties and oral bioavailability compared to the natural form of genistein, and...
13.
Sclafani F, Kim T, Cunningham D, Kim T, Tabernero J, Schmoll H, et al.
J Natl Cancer Inst
. 2015 Sep;
107(12):djv258.
PMID: 26405092
Background: Insulin-like growth factor type 1 receptor (IGF-1R) mediates resistance to epidermal growth factor receptor (EGFR) inhibition and may represent a therapeutic target. We conducted a multicenter, randomized, double blind,...
14.
Buchli C, Abani M, Ahlberg M, Holm T, Fokstuen T, Bottai M, et al.
Acta Oncol
. 2015 Sep;
55(4):496-501.
PMID: 26362484
Background: Radiotherapy (RT) for rectal cancer can have adverse effects on testicular function resulting in azoospermia and low testosterone levels. Variability of testicular dose (TD) due to differences in position...
15.
Ekman S, Harmenberg J, Frodin J, Bergstrom S, Wassberg C, Eksborg S, et al.
Acta Oncol
. 2015 Jul;
55(2):140-8.
PMID: 26161618
Background: A phase Ia/b dose-escalation study was performed to characterize the safety, efficacy and pharmacokinetic properties of the oral small molecule insulin-like growth factor-1-receptor pathway modulator AXL1717 in patients with...
16.
Fuentes S, Frodin J
Acta Oncol
. 2015 Jan;
54(7):1056-62.
PMID: 25591938
Background: Chemotherapy and targeted drugs are important tools in the treatment of malignant diseases. A number of the planned treatments are cancelled late which is a great challenge for the...
17.
Staff C, Mozaffari F, Frodin J, Mellstedt H, Liljefors M
Int J Oncol
. 2014 Jun;
45(3):1293-303.
PMID: 24919654
Telomerase is expressed in 85-90 % of pancreatic adenocarcinomas and might be a target for active cancer immunotherapy. A study was conducted to investigate safety and immunogenicity in non-resectable pancreatic...
18.
Staff C, Magnusson C, Hojjat-Farsangi M, Mosolits S, Liljefors M, Frodin J, et al.
J Clin Immunol
. 2012 Mar;
32(4):855-65.
PMID: 22382876
Purpose: Previous clinical studies have indicated that natural IgM antibodies have the ability to induce apoptosis of tumor cells but IgE and IgA may also mediate tumor cell killing (in...
19.
Ekman S, Frodin J, Harmenberg J, Bergman A, Hedlund A, Dahg P, et al.
Acta Oncol
. 2010 Aug;
50(3):441-7.
PMID: 20698809
Background: Inhibition of the Insulin-like Growth Factor-1 receptor (IGF-1R) has resulted in extensive anti-tumor effects. Picropdophyllin (PPP, AXL1717) is a small-molecule inhibitor of the IGF-1R without inhibition of closely related...
20.
Berglund A, Bystrom P, Johansson B, Nygren P, Frodin J, Pedersen D, et al.
Med Oncol
. 2009 Feb;
27(1):65-72.
PMID: 19212708
The feasibility, safety, and efficacy of planned sequential administration of docetaxel and irinotecan with 5-fluorouracil (5-FU)/leucovorin in advanced upper gastrointestinal adenocarcinoma (UGIA) are unknown. Seventy-three patients with gastric (GC; n...