Jamil Nehme
Overview
Explore the profile of Jamil Nehme including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
1178
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0
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Recent Articles
1.
Nehme J, Maassen S, Bravaccini S, Zanoni M, Gianni C, De Giorgi U, et al.
EMBO J
. 2025 Feb;
PMID: 39930269
Breast cancer is a leading cause of mortality worldwide. Pharmacological inhibitors of cyclin-dependent kinases (CDK) 4 and 6 (CDK4/6i) inhibit breast cancer growth by inducing a senescent-like state. However, the...
2.
Nehme J, Mesilmany L, Varela-Eirin M, Brandenburg S, Altulea A, Lin Y, et al.
Nat Aging
. 2024 May;
4(6):771-782.
PMID: 38724734
Excessive amounts of reactive oxygen species (ROS) lead to macromolecular damage and high levels of cell death with consequent pathological sequelae. We hypothesized that switching cell death to a tissue...
3.
Linders A, Dias I, Ovchinnikova E, Vermeer M, Hoes M, Markousis Mavrogenis G, et al.
JACC CardioOncol
. 2023 Jul;
5(3):298-315.
PMID: 37397084
Background: Doxorubicin is an essential cancer treatment, but its usefulness is hampered by the occurrence of cardiotoxicity. Nevertheless, the pathophysiology underlying doxorubicin-induced cardiotoxicity and the respective molecular mechanisms are poorly...
4.
Nehme J, Altulea A, Gheorghe T, Demaria M
Biomed J
. 2023 Feb;
46(3):100585.
PMID: 36801257
Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. For this reason, dietary interventions and compounds perturbing...
5.
Nehme J, Yang D, Altulea A, Varela-Eirin M, Wang L, Hu S, et al.
FEBS J
. 2021 Dec;
290(5):1340-1347.
PMID: 34908245
Dietary choices have a profound impact on the aging process. In addition to the total amount of energy intake, macronutrient composition influences both health and lifespan. However, the exact mechanisms...
6.
Nehme J, Borghesan M, Mackedenski S, Bird T, Demaria M
Aging Cell
. 2020 Sep;
19(10):e13237.
PMID: 32955770
SARS-CoV-2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID-19), a complex respiratory distress syndrome. Epidemiological data show that COVID-19 has a...
7.
Fontana L, Nehme J, Demaria M
Mech Ageing Dev
. 2018 Nov;
176:19-23.
PMID: 30395873
Cellular senescence is a state of irreversible growth arrest characterized by hypertrophy and secretion of various bioactive molecules, a phenomenon defined the Senescence-Associated Secretory Phenotype (SASP). Senescent cells are implicated...
8.
Hernandez-Segura A, Nehme J, Demaria M
Trends Cell Biol
. 2018 Feb;
28(6):436-453.
PMID: 29477613
Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential...