James W Opzoomer
Overview
Explore the profile of James W Opzoomer including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
304
Followers
0
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Recent Articles
1.
De Jonghe J, Opzoomer J, Vilas-Zornoza A, Nilges B, Crane P, Vicari M, et al.
Cell Genom
. 2024 Dec;
4(12):100723.
PMID: 39667347
Understanding the rapidly evolving landscape of single-cell and spatial omic technologies is crucial for advancing biomedical research and drug development. We provide a living review of both mature and emerging...
2.
Zapatero M, Tong A, Opzoomer J, OSullivan R, Cardoso Rodriguez F, Sufi J, et al.
Cell
. 2024 Nov;
187(25):7335-7349.
PMID: 39603238
No abstract available.
3.
De Jonghe J, Opzoomer J, Vilas-Zornoza A, Crane P, Nilges B, Vicari M, et al.
Nat Biotechnol
. 2024 Jul;
42(7):1017-1023.
PMID: 39020213
No abstract available.
4.
Zapatero M, Tong A, Opzoomer J, OSullivan R, Cardoso Rodriguez F, Sufi J, et al.
Cell
. 2023 Dec;
186(25):5606-5619.e24.
PMID: 38065081
Patient-derived organoids (PDOs) can model personalized therapy responses; however, current screening technologies cannot reveal drug response mechanisms or how tumor microenvironment cells alter therapeutic performance. To address this, we developed...
5.
Anstee J, Feehan K, Opzoomer J, Dean I, Muller H, Bahri M, et al.
Dev Cell
. 2023 Jul;
58(17):1548-1561.e10.
PMID: 37442140
Tumor-associated macrophages (TAMs) are a heterogeneous population of cells that facilitate cancer progression. However, our knowledge of the niches of individual TAM subsets and their development and function remain incomplete....
6.
Bahri M, Anstee J, Opzoomer J, Arnold J
Essays Biochem
. 2023 May;
67(6):919-928.
PMID: 37199172
Perivascular (Pv) tumor-associated macrophages (TAMs) are a highly specialized stromal subset within the tumor microenvironment (TME) that are defined by their spatial proximity, within one cell thickness, to blood vasculature....
7.
Barber P, Mustapha R, Flores-Borja F, Alfano G, Ng K, Weitsman G, et al.
Elife
. 2022 Dec;
11.
PMID: 36562609
Background: Advanced head and neck squamous cell carcinoma (HNSCC) is associated with a poor prognosis, and biomarkers that predict response to treatment are highly desirable. The primary aim was to...
8.
Opzoomer J, Anstee J, Dean I, Hill E, Bouybayoune I, Caron J, et al.
Sci Adv
. 2021 Nov;
7(45):eabg9518.
PMID: 34730997
Tumor-associated macrophages (TAMs) are a highly plastic stromal cell type that support cancer progression. Using single-cell RNA sequencing of TAMs from a spontaneous murine model of mammary adenocarcinoma (), we...
9.
Kosti P, Opzoomer J, Larios-Martinez K, Henley-Smith R, Scudamore C, Okesola M, et al.
Cell Rep Med
. 2021 May;
2(4):100227.
PMID: 33948568
Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid tumors has proven challenging, in large part because of the lack of tumor-specific targets to direct CAR...
10.
Opzoomer J, Timms J, Blighe K, Mourikis T, Chapuis N, Bekoe R, et al.
Elife
. 2021 Apr;
10.
PMID: 33929322
High-dimensional cytometry is an innovative tool for immune monitoring in health and disease, and it has provided novel insight into the underlying biology as well as biomarkers for a variety...