James W Lightfoot
Overview
Explore the profile of James W Lightfoot including associated specialties, affiliations and a list of published articles.
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17
Citations
235
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Recent Articles
1.
Goetting D, Lightfoot J
Trends Parasitol
. 2025 Feb;
41(3):175-176.
PMID: 39939272
Skin-penetrating nematodes such as Strongyloides stercoralis depend on a suite of chemosensory cues to find their host. Banerjee et al. uncovered life-stage-specific behavioral preferences for CO in S. stercoralis and...
2.
Kotowska A, Hiramatsu F, Alexander M, Scurr D, Lightfoot J, Chauhan V
J Am Chem Soc
. 2025 Feb;
147(8):6439-6449.
PMID: 39936408
The surface of an organism is a dynamic interface that continually adapts to its environment. In nematodes, the cuticle forms a complex boundary that protects against the physicochemical pressures. However,...
3.
Hiramatsu F, Lightfoot J
PLoS Genet
. 2023 Dec;
19(12):e1011056.
PMID: 38096160
Kin-recognition is observed across diverse species forming an important behavioral adaptation influencing organismal interactions. In many species, the molecular mechanisms involved are difficult to characterize, but in the nematode Pristionchus...
4.
Dardiry M, Eberhard G, Witte H, Rodelsperger C, Lightfoot J, Sommer R
PLoS Biol
. 2023 Aug;
21(8):e3002270.
PMID: 37590316
The widespread occurrence of phenotypic plasticity across all domains of life demonstrates its evolutionary significance. However, how plasticity itself evolves and how it contributes to evolution is poorly understood. Here,...
5.
Roca M, Lightfoot J
Curr Biol
. 2023 May;
33(9):R361-R363.
PMID: 37160094
Cannabinoids can enhance the preference for calorific foods through hedonic feeding behaviors. A new study identifies and characterizes these indulgent behaviors in the nematode Caenorhabditis elegans, providing insights into the...
6.
Lo W, Roca M, Dardiry M, Mackie M, Eberhardt G, Witte H, et al.
Mol Biol Evol
. 2022 Dec;
39(12).
PMID: 36469861
Transforming growth factor-β (TGF-β) signaling is essential for numerous biologic functions. It is a highly conserved pathway found in all metazoans including the nematode Caenorhabditis elegans, which has also been...
7.
Eren G, Roca M, Han Z, Lightfoot J
MicroPubl Biol
. 2022 Jun;
2022.
PMID: 35693893
Transgenes are widely used throughout molecular biology for numerous applications. In stable transgenes are usually generated by microinjection into the germline establishing extrachromosomal arrays. Furthermore, numerous technologies exist to integrate...
8.
Lightfoot J, Dardiry M, Kalirad A, Giaimo S, Eberhardt G, Witte H, et al.
Sci Adv
. 2021 Aug;
7(35).
PMID: 34433565
Resource polyphenisms, where single genotypes produce alternative feeding strategies in response to changing environments, are thought to be facilitators of evolutionary novelty. However, understanding the interplay between environment, morphology, and...
9.
Han Z, Lo W, Lightfoot J, Witte H, Sun S, Sommer R
Genetics
. 2020 Oct;
216(4):947-956.
PMID: 33060138
A lack of appropriate molecular tools is one obstacle that prevents in-depth mechanistic studies in many organisms. Transgenesis, clustered regularly interspaced short palindromic repeats (CRISPR)-associated engineering, and related tools are...
10.
Sieriebriennikov B, Sun S, Lightfoot J, Witte H, Moreno E, Rodelsperger C, et al.
PLoS Genet
. 2020 Apr;
16(4):e1008687.
PMID: 32282814
Environment shapes development through a phenomenon called developmental plasticity. Deciphering its genetic basis has potential to shed light on the origin of novel traits and adaptation to environmental change. However,...