James W Janetka
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Explore the profile of James W Janetka including associated specialties, affiliations and a list of published articles.
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58
Citations
1733
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Recent Articles
1.
Azimzadeh P, Birchenough G, Gualbuerto N, Pinkner J, Tamadonfar K, Beatty W, et al.
Sci Adv
. 2025 Jan;
11(5):eadp7066.
PMID: 39888987
Urinary tract infections (UTIs) are highly recurrent and frequently caused by Uropathogenic (UPEC) strains that can be found in patient intestines. Seeding of the urinary tract from this intestinal reservoir...
2.
Banas V, Elfawal M, Rosa B, Mahoney M, Kauffman J, Goetz E, et al.
ACS Infect Dis
. 2025 Jan;
11(2):506-517.
PMID: 39828994
Soil-transmitted helminth (STH) infections affect one-fourth of the global population and pose a significant threat to human and animal health, with limited treatment options and emerging drug resistance. (whipworm) stands...
3.
Lopatto E, Pinkner J, Sanick D, Potter R, Liu L, Villicana J, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(39):e2409655121.
PMID: 39288182
is an important pathogen causing difficult-to-treat urinary tract infections (UTIs). Over 1.5 million women per year suffer from recurrent UTI, reducing quality of life and causing substantial morbidity and mortality,...
4.
Mahoney M, Helander J, Kooner A, Norman M, Damalanka V, De Bona P, et al.
Protein Sci
. 2024 Jul;
33(8):e5110.
PMID: 39073183
Inhibition of the proteolytic processing of hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP) is an attractive approach for the drug discovery of novel anticancer therapeutics which prevent tumor...
5.
Boon A, Bricker T, Fritch E, Leist S, Gully K, Baric R, et al.
J Virol
. 2024 Apr;
98(5):e0190323.
PMID: 38593045
Importance: SARS-CoV-2 and other emerging RNA coronaviruses are a present and future threat in causing widespread endemic and pandemic infection and disease. In this paper, we have shown that the...
6.
Damalanka V, Banas V, De Bona P, Kashipathy M, Battaile K, Lovell S, et al.
J Med Chem
. 2024 Mar;
67(6):4833-4854.
PMID: 38477709
Protease inhibitor drug discovery is challenged by the lack of cellular and oral permeability, selectivity, metabolic stability, and rapid clearance of peptides. Here, we describe the rational design, synthesis, and...
7.
Boon A, Bricker T, Fritch E, Leist S, Gully K, Baric R, et al.
bioRxiv
. 2024 Feb;
PMID: 38405752
Importance: SARS-CoV-2 and other emerging RNA coronaviruses are a present and future threat in causing widespread endemic and pandemic infection and disease. In this paper, we have shown that the...
8.
Maddirala A, Tamadonfar K, Pinkner J, Sanick D, Hultgren S, Janetka J
J Med Chem
. 2024 Feb;
67(5):3668-3678.
PMID: 38308631
FmlH, a bacterial adhesin of uropathogenic (UPEC), has been shown to provide a fitness advantage in colonizing the bladder during chronic urinary tract infections (UTIs). Previously reported -biphenyl glycosides based...
9.
Obermann R, Yemane B, Jarvis C, Franco F, Kyriukha Y, Nolan W, et al.
ChemMedChem
. 2024 Feb;
19(8):e202300648.
PMID: 38300970
The DNA excision repair protein ERCC1 and the DNA damage sensor protein, XPA are highly overexpressed in patient samples of cisplatin-resistant solid tumors including lung, bladder, ovarian, and testicular cancer....
10.
Jones V, Graves-Deal R, Cao Z, Bogatcheva G, Ramirez M, Harmych S, et al.
Cell Mol Life Sci
. 2024 Jan;
81(1):28.
PMID: 38212428
Although amplifications and mutations in receptor tyrosine kinases (RTKs) act as bona fide oncogenes, in most cancers, RTKs maintain moderate expression and remain wild-type. Consequently, cognate ligands control many facets...