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James V Bruckner

Explore the profile of James V Bruckner including associated specialties, affiliations and a list of published articles. Areas
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Articles 41
Citations 289
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Recent Articles
1.
Pang J, Mortuza T, White C, Muralidhara S, Cummings B, Bruckner J
Toxicol Sci . 2019 Dec; 174(1):25-37. PMID: 31808824
Permethrin exposure of children and adults is widespread in many populations, but knowledge of its relative toxicokinetics (TK) and health risks in immature age groups is lacking. Studies were conducted...
2.
Sethi P, Bruckner J, Mortuza T, Cummings B, Muralidhara S, White C
Drug Metab Dispos . 2019 Jun; 47(9):941-948. PMID: 31248885
The majority of residents of the United States, Canada, and Europe are exposed to pyrethroids, the most commonly used class of insecticides. Surprisingly little is known about key aspects of...
3.
Song G, Moreau M, Efremenko A, Lake B, Wu H, Bruckner J, et al.
Toxicol Sci . 2019 Feb; 169(2):365-379. PMID: 30768128
An in vitro to in vivo (IVIVE) extrapolation based-physiologically based pharmacokinetic (PBPK) modeling approach was demonstrated to understand age-related differences in kinetics and how they potentially affect age-related differences in...
4.
Mortuza T, Edwards G, White C, Patel V, Cummings B, Bruckner J
Drug Metab Dispos . 2018 Dec; 47(3):234-237. PMID: 30523003
Permethrin (PER), a type I pyrethroid, is the most widely used insecticide in domestic settings in the United States. The overall objective of this study was to assess the efficiency...
5.
Mortuza T, Muralidhara S, White C, Cummings B, Hines C, Bruckner J
Toxicol Appl Pharmacol . 2018 Oct; 360:185-192. PMID: 30287391
Trichloroethylene (TCE) and 1,1,1-trichloroethane (TRI) are frequent contaminants of drinking water and of groundwater at hazardous waste sites. There is relatively little information on the target organ deposition of TRI,...
6.
Mortuza T, Chen C, White C, Cummings B, Muralidhara S, Gullick D, et al.
Toxicol Sci . 2017 Nov; 162(1):327-336. PMID: 29165640
There is increasing concern that infants and children may be at increased risk of neurological effects of pyrethroids, the most widely used class of insecticide. The objectives of this investigation...
7.
Hooshfar S, Mortuza T, Rogers C, Linzey M, Gullick D, Bruckner J, et al.
Rapid Commun Mass Spectrom . 2017 Jul; 31(19):1573-1581. PMID: 28708331
Rationale: Transfluthrin is a relatively non-toxic rapid-acting synthetic pyrethroid insecticide. It is widely used in household and hygiene products. A sensitive and accurate bioanalytical method is required for quantification of...
8.
Hooshfar S, Gullick D, Linzey M, Mortuza T, Abdel Rahman M, Rogers C, et al.
J Chromatogr B Analyt Technol Biomed Life Sci . 2017 Jun; 1060:291-299. PMID: 28651172
A sensitive method for the simultaneous determination of cis-permethrin (cis-PERM) and trans-permethrin (trans-PERM) in small volumes (100μL) of rat plasma and brain homogenate was developed, using a liquid-liquid extraction for...
9.
Amaraneni M, Pang J, Mortuza T, Muralidhara S, Cummings B, White C, et al.
Neurotoxicology . 2017 May; 62:24-29. PMID: 28495520
Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats...
10.
Amaraneni M, Pang J, Bruckner J, Muralidhara S, Mortuza T, Gullick D, et al.
J Pharm Sci . 2017 Apr; 106(8):2144-2151. PMID: 28445697
Permethrin, the most widely used household insecticide in the United States, is marketed as a mixture of its cis (CIS) and trans (TRANS) isomers. The major objective of this investigation...