James T Stull
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Explore the profile of James T Stull including associated specialties, affiliations and a list of published articles.
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48
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1829
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Recent Articles
1.
Chen J, Kaw K, Lu H, Fagnant P, Chattopadhyay A, Duan X, et al.
J Biol Chem
. 2021 Oct;
297(6):101228.
PMID: 34600884
Pathogenic variants of the gene for smooth muscle α-actin (ACTA2), which encodes smooth muscle (SM) α-actin, predispose to heritable thoracic aortic disease. The ACTA2 variant p.Arg149Cys (R149C) is the most...
2.
Chang A, Gao N, Liu Z, Huang J, Nairn A, Kamm K, et al.
J Biol Chem
. 2018 Sep;
293(43):16677-16686.
PMID: 30185619
Contractile force development of smooth muscle is controlled by balanced kinase and phosphatase activities toward the myosin regulatory light chain (RLC). Numerous biochemical and pharmacological studies have investigated the specificity...
3.
Kwartler C, Gong L, Chen J, Wang S, Kulmacz R, Duan X, et al.
Am J Hum Genet
. 2018 Jul;
103(1):138-143.
PMID: 29961567
Thoracic aortic aneurysms leading to acute aortic dissections are a preventable cause of premature deaths if individuals at risk can be identified. Individuals with early-onset aortic dissections without a family...
4.
Huang J, Gao N, Wang S, Milewicz D, Kamm K, Stull J
PLoS One
. 2018 Mar;
13(3):e0193769.
PMID: 29494672
Aortic smooth muscle contains limiting amounts of myosin light chain kinase (MLCK) for myosin regulatory light chain (RLC) phosphorylation and contraction that predisposes to thoracic aortic disease in humans containing...
5.
Gao N, Tsai M, Chang A, He W, Chen C, Zhu M, et al.
J Physiol
. 2017 Jul;
595(19):6231-6247.
PMID: 28749013
Key Points: Smooth muscle myosin regulatory light chain (RLC) is phosphorylated by Ca /calmodulin-dependent myosin light chain kinase and dephosphorylated by myosin light chain phosphatase (MLCP). Tracheal smooth muscle contains...
6.
Liu Z, Chang A, Grinnell F, Trybus K, Milewicz D, Stull J, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(28):E5569-E5578.
PMID: 28652363
The most common genetic alterations for familial thoracic aortic aneurysms and dissections (TAAD) are missense mutations in vascular smooth muscle (SM) α-actin encoded by We focus here on R258C, a...
7.
Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections
Milewicz D, Trybus K, Guo D, Sweeney H, Regalado E, Kamm K, et al.
Arterioscler Thromb Vasc Biol
. 2016 Nov;
37(1):26-34.
PMID: 27879251
The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is evident by the fact that heterozygous mutations in the major structural proteins or kinases controlling contraction lead...
8.
Chang A, Kamm K, Stull J
J Mol Cell Cardiol
. 2016 Oct;
101:35-43.
PMID: 27742556
Maintenance of contractile performance of the heart is achieved in part by the constitutive 40% phosphorylation of myosin regulatory light chain (RLC) in sarcomeres. The importance of this extent of...
9.
Chang A, Mahajan P, Knapp S, Barton H, Sweeney H, Kamm K, et al.
Proc Natl Acad Sci U S A
. 2016 Jun;
113(27):E3824-33.
PMID: 27325775
The well-known, muscle-specific smooth muscle myosin light chain kinase (MLCK) (smMLCK) and skeletal muscle MLCK (skMLCK) are dedicated protein kinases regulated by an autoregulatory segment C terminus of the catalytic...
10.
Gao N, Chang A, He W, Chen C, Qiao Y, Zhu M, et al.
J Physiol
. 2016 Feb;
594(12):3209-25.
PMID: 26847850
Key Points: The extent of myosin regulatory light chain phosphorylation (RLC) necessary for smooth muscle contraction depends on the respective activities of Ca(2+) /calmodulin-dependent myosin light chain kinase and myosin...