James S Sutcliffe
Overview
Explore the profile of James S Sutcliffe including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
98
Citations
16401
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Hope K, Flatten D, Cavitch P, May B, Sutcliffe J, ODonnell J, et al.
Front Genet
. 2019 Jul;
10:574.
PMID: 31316544
Major challenges to identifying genes that contribute to autism spectrum disorder (ASD) risk include the availability of large ASD cohorts, the contribution of many genes overall, and small effect sizes...
12.
Wang Q, Chen R, Cheng F, Wei Q, Ji Y, Yang H, et al.
Nat Neurosci
. 2019 Apr;
22(5):691-699.
PMID: 30988527
Genome-wide association studies (GWAS) have identified more than 100 schizophrenia (SCZ)-associated loci, but using these findings to illuminate disease biology remains a challenge. Here we present integrative risk gene selector...
13.
Campbell N, Shekar A, Aguilar J, Peng D, Navratna V, Yang D, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(9):3853-3862.
PMID: 30755521
The human dopamine (DA) transporter (hDAT) mediates clearance of DA. Genetic variants in hDAT have been associated with DA dysfunction, a complication associated with several brain disorders, including autism spectrum...
14.
Montgomery A, Shuffrey L, Guter S, Anderson G, Jacob S, Mosconi M, et al.
J Am Acad Child Adolesc Psychiatry
. 2018 Nov;
57(11):867-875.
PMID: 30392628
Objective: The serotonin (5-hydroxytryptamine [HT]) system has long been implicated in autism spectrum disorder (ASD). Whole-blood 5-HT level (WB5-HT) is a stable, heritable biomarker that is elevated in more than...
15.
Dohn M, Kooker C, Bastarache L, Jessen T, Rinaldi C, Varney S, et al.
J Neurosci
. 2017 Oct;
37(46):11271-11284.
PMID: 29038237
Engagement of integrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain. Multiple lines of evidence...
16.
Shuffrey L, Guter S, Delaney S, Jacob S, Anderson G, Sutcliffe J, et al.
Autism Res
. 2017 Apr;
10(8):1417-1423.
PMID: 28401654
Approximately 30% of individuals with autism spectrum disorder (ASD) have elevated whole blood serotonin (5-HT) levels. Genetic linkage and association studies of ASD and of whole blood 5-HT levels as...
17.
Chen R, Davis L, Guter S, Wei Q, Jacob S, Potter M, et al.
Mol Autism
. 2017 Mar;
8:14.
PMID: 28344757
Background: Autism spectrum disorder (ASD) is one of the most highly heritable neuropsychiatric disorders, but underlying molecular mechanisms are still unresolved due to extreme locus heterogeneity. Leveraging meaningful endophenotypes or...
18.
Veatch O, Sutcliffe J, Warren Z, Keenan B, Potter M, Malow B
Autism Res
. 2017 Mar;
10(7):1221-1238.
PMID: 28301091
Sleep disturbance, particularly insomnia, is common in children with autism spectrum disorders (ASD). Furthermore, disturbed sleep affects core symptoms and other related comorbidities. Understanding the causes and consequences of sleep...
19.
Stephenson J, Wang X, Perfitt T, Parrish W, Shonesy B, Marks C, et al.
J Neurosci
. 2017 Jan;
37(8):2216-2233.
PMID: 28130356
Characterizing the functional impact of novel mutations linked to autism spectrum disorder (ASD) provides a deeper mechanistic understanding of the underlying pathophysiological mechanisms. Here we show that a Glu183 to...
20.
Yan Q, Chen R, Sutcliffe J, Cook E, Weeks D, Li B, et al.
Sci Rep
. 2016 Jun;
6:28323.
PMID: 27328765
Family-based sequencing studies have unique advantages in enriching rare variants, controlling population stratification, and improving genotype calling. Standard genotype calling algorithms are less likely to call rare variants correctly, often...