James S Polakowski
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Explore the profile of James S Polakowski including associated specialties, affiliations and a list of published articles.
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30
Citations
221
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Recent Articles
1.
Watson M, Brar H, Gibbs 2nd E, Wong H, Dighe P, McKibben B, et al.
Free Radic Biol Med
. 2023 May;
204:276-286.
PMID: 37217089
We developed S1QEL1.719, a novel bioavailable S1QEL (suppressor of site I electron leak). S1QEL1.719 prevented superoxide/hydrogen peroxide production at site I of mitochondrial complex I in vitro. The free concentration...
2.
Koshman Y, Wilsey A, Bird B, Sadilek S, Weisbecker D, Ebert P, et al.
J Pharmacol Toxicol Methods
. 2021 Aug;
111:107109.
PMID: 34416395
Introduction: A successful integration of automated blood sampling (ABS) into the telemetry instrumented canine cardiovascular model is presented in this study. This combined model provides an efficient means to quickly...
3.
Koshman Y, Lai-Zhang J, Wilsey A, Bird B, Sadilek S, Weisbecker D, et al.
J Pharmacol Toxicol Methods
. 2021 Aug;
112:107115.
PMID: 34403748
Introduction: This manuscript presents a successful integration of multi-timepoint biomarker blood sampling (e.g., cytokines) in a conscious dog cardiovascular study using automated blood sampling via vascular access ports in telemetry...
4.
Koshman Y, Wilsey A, Bird B, Sadilek S, Weisbecker D, Ebert P, et al.
J Pharmacol Toxicol Methods
. 2021 Apr;
109:107066.
PMID: 33838254
Introduction: A successful integration of automated blood sampling (ABS) into the telemetry instrumented canine cardiovascular model is presented in this study. This combined model provides an efficient means to quickly...
5.
Wilsey A, Koshman Y, Weisbecker D, Bird B, Mirakhur K, Sadilek S, et al.
Comp Med
. 2021 Apr;
71(2):133-140.
PMID: 33814031
Successful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug...
6.
Koshman Y, Wilsey A, Bird B, Endemann A, Sadilek S, Treadway J, et al.
J Pharmacol Toxicol Methods
. 2020 May;
103:106871.
PMID: 32360993
Introduction: The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative differentiates torsadogenic risk of 28 drugs affecting ventricular repolarization based on multiple in vitro human derived ionic currents. However, a standardized...
7.
Koshman Y, Herzberg B, Seifert T, Polakowski J, Mittelstadt S
J Pharmacol Toxicol Methods
. 2018 Jan;
91:27-35.
PMID: 29330133
Introduction: The goal of this study was to determine whether assessment of myocardial contractility and hemodynamics in an anesthetized dog model, could consistently detect drug-induced changes in the inotropic state...
8.
Segreti J, Polakowski J, Blomme E, King A
J Pharmacol Toxicol Methods
. 2016 Jan;
79:23-33.
PMID: 26778372
Comprehensive cardiovascular assessment in conscious rodents by utilizing telemetry has been limited by the restriction of current devices to one pressure channel. The purpose of this study was to test...
9.
Voight E, Gomtsyan A, Daanen J, Perner R, Schmidt R, Bayburt E, et al.
J Med Chem
. 2014 Aug;
57(17):7412-24.
PMID: 25100568
The synthesis and characterization of a series of selective, orally bioavailable 1-(chroman-4-yl)urea TRPV1 antagonists is described. Whereas first-generation antagonists that inhibit all modes of TRPV1 activation can elicit hyperthermia, the...
10.
Esbenshade T, Browman K, Miller T, Krueger K, Komater-Roderwald V, Zhang M, et al.
J Pharmacol Exp Ther
. 2012 Jul;
343(1):233-45.
PMID: 22815533
Blockade of the histamine H(3) receptor (H(3)R) enhances central neurotransmitter release, making it an attractive target for the treatment of cognitive disorders. Here, we present in vitro and in vivo...