James R Pena
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Explore the profile of James R Pena including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
198
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Recent Articles
1.
Solis C, Thompson W, Pena J, McDermott-Roe C, Langa P, Warren C, et al.
Front Physiol
. 2022 Dec;
13:1028345.
PMID: 36467694
In the heart, alternative splicing of the gene produces two isoforms: IGF-IEa and IGF-IEc, (Mechano-growth factor, MGF). The sequence divergence between their E-domain regions suggests differential isoform function. To define...
2.
Pena J, Pinney J, Ayala P, Desai T, Goldspink P
Biomaterials
. 2015 Feb;
46:26-34.
PMID: 25678113
The Insulin like growth factor-I isoform mechano-growth factor (MGF), is expressed in the heart following myocardial infarction and encodes a unique E-domain region. To examine E-domain function, we delivered a...
3.
Rajan S, Pena J, Jegga A, Aronow B, Wolska B, Wieczorek D
Physiol Genomics
. 2013 Jun;
45(17):764-73.
PMID: 23800848
Familial hypertrophic cardiomyopathy (FHC) is a disease characterized by ventricular hypertrophy, fibrosis, and aberrant systolic and/or diastolic function. Our laboratories have previously developed two mouse models that affect cardiac performance....
4.
Gaffin R, Pena J, Alves M, Dias F, Chowdhury S, Heinrich L, et al.
J Mol Cell Cardiol
. 2011 Aug;
51(5):812-20.
PMID: 21840315
We have recently shown that a temporary increase in sarcoplasmic reticulum (SR) cycling via adenovirus-mediated overexpression of sarcoplasmic reticulum ATPase (SERCA2) transiently improves relaxation and delays hypertrophic remodeling in a...
5.
Pena J, Szkudlarek A, Warren C, Heinrich L, Gaffin R, Jagatheesan G, et al.
J Mol Cell Cardiol
. 2010 Sep;
49(6):993-1002.
PMID: 20854827
Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant genetic disorder linked to numerous mutations in the sarcomeric proteins. The clinical presentation of FHC is highly variable, but it is a...
6.
Dias F, Urboniene D, Yuzhakova M, Biesiadecki B, Pena J, Goldspink P, et al.
Front Biosci (Elite Ed)
. 2009 Dec;
2(1):312-24.
PMID: 20036880
We investigated the role of inducible NOS (iNOS) on cardiac function during the development of left ventricular hypertrophy. Hypertrophy was induced by pressure-overload via short-term (2.5 months) or long-term (6.5...
7.
Nowak G, Pena J, Urboniene D, Geenen D, Solaro R, Wolska B
J Muscle Res Cell Motil
. 2008 Mar;
28(7-8):415-9.
PMID: 18365757
We have tested the hypothesis that alterations in length dependent activation (LDA) of cardiac myofilaments represent an important regulatory mechanism affecting the Frank-Starling mechanism as determined by the slope (E(es))...
8.
Bupha-Intr T, Wattanapermpool J, Pena J, Wolska B, Solaro R
Am J Physiol Regul Integr Comp Physiol
. 2006 Oct;
292(2):R837-43.
PMID: 17038443
Compared to sham-operated controls, myofilaments from hearts of ovariectomized (OVX) rats demonstrate an increase in Ca2+ sensitivity with no change in maximum tension (Wattanapermpool J and Reiser PJ. Am J...
9.
Dias F, Walker L, Arteaga G, Walker J, Vijayan K, Pena J, et al.
J Mol Cell Cardiol
. 2006 Jun;
41(2):330-9.
PMID: 16806259
Although it has been suggested that in cardiac muscle the phosphorylation level of myosin regulatory light chain (RLC) correlates with frequency of stimulation, its significance in the modulation of the...
10.
Urboniene D, Dias F, Pena J, Walker L, Solaro R, Wolska B
Circ Res
. 2005 Jun;
97(1):70-7.
PMID: 15961720
Compared with the adult, neonatal heart muscle is less sensitive to deactivation by acidic pH. We hypothesized that expression of slow skeletal troponin I (ssTnI), the embryonic isoform, in adult...