James R Pancoast
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Explore the profile of James R Pancoast including associated specialties, affiliations and a list of published articles.
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11
Citations
1183
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Recent Articles
1.
Walker R, Barrandon O, Poggioli T, Dagdeviren S, Carroll S, Mills M, et al.
Sci Rep
. 2020 Mar;
10(1):4561.
PMID: 32165710
Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal...
2.
Mahmoud A, Galdos F, Dinan K, Jedrychowski M, Davis J, Vujic A, et al.
PLoS One
. 2018 Oct;
13(10):e0204595.
PMID: 30303984
The in vivo microenvironment of tissues provides myriad unique signals to cells. Thus, following isolation, many cell types change in culture, often preserving some but not all of their in...
3.
Rachmin I, OMeara C, Ricci-Blair E, Feng Y, Christensen E, Duffy J, et al.
Am J Physiol Endocrinol Metab
. 2017 Sep;
313(6):E663-E671.
PMID: 28874358
Soluble IL-13 receptor-α1, or sIL13rα1, is a soluble protein that binds to interleukin-13 (IL-13) that has been previously described in mice. The function of sIL13rα1 remains unclear, but it has...
4.
Liebesny P, Byun S, Hung H, Pancoast J, Mroszczyk K, Young W, et al.
Tissue Eng Part A
. 2016 Jun;
22(13-14):917-27.
PMID: 27268956
Tissue engineering approaches using growth factor-functionalized acellular scaffolds to support and guide repair driven by endogenous cells are thought to require a careful balance between cell recruitment and growth factor...
5.
Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo F, et al.
Circ Res
. 2015 Oct;
118(1):29-37.
PMID: 26489925
Rationale: Growth differentiation factor 11 (GDF11) and GDF8 are members of the transforming growth factor-β superfamily sharing 89% protein sequence homology. We have previously shown that circulating GDF11 levels decrease...
6.
Loffredo F, Nikolova A, Pancoast J, Lee R
Circ Res
. 2014 Jun;
115(1):97-107.
PMID: 24951760
Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection...
7.
Sinha M, Jang Y, Oh J, Khong D, Wu E, Manohar R, et al.
Science
. 2014 May;
344(6184):649-52.
PMID: 24797481
Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral "rejuvenating" factors that can restore regenerative function....
8.
Loffredo F, Pancoast J, Cai L, Vannelli T, Dong J, Lee R, et al.
Arthritis Rheumatol
. 2014 Jan;
66(5):1247-55.
PMID: 24470361
Objective: Acute articular injuries lead to an increased risk of progressive joint damage and osteoarthritis (OA), and no therapies are currently available to repair or protect the injured joint tissue....
9.
Li W, Lee S, Ma M, Kim S, Guye P, Pancoast J, et al.
Sci Rep
. 2013 Oct;
3:2863.
PMID: 24091640
Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and...
10.
Loffredo F, Pancoast J, Lee R
Circ Res
. 2013 Jul;
113(2):97-9.
PMID: 23833289
Aging is a major factor in many cardiovascular diseases. The molecular factors that regulate age-related changes in cardiac physiology and contribute to the increased cardiovascular risk in the elderly are...