James R OSiorain
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Explore the profile of James R OSiorain including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
137
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0
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Recent Articles
1.
OSiorain J, Cox S, Payet C, Nally F, He Y, Drewinksi T, et al.
FASEB J
. 2024 Dec;
38(24):e70235.
PMID: 39686706
Macrophages are innate immune cells that orchestrate the process of inflammation, which varies across time of day. This ensures appropriate biological timing of the immune response with the external environment....
2.
Cox S, OSiorain J, He Y, Lordan R, Naik A, Tang S, et al.
FASEB J
. 2023 Jan;
37(2):e22753.
PMID: 36624683
Fibroblasts are stromal cells abundant throughout tissues, including the lungs. Fibroblasts are integral coordinators of immune cell recruitment through chemokine secretion. Circadian rhythms direct the recruitment of immune cells to...
3.
Cervantes-Silva M, Carroll R, Wilk M, Moreira D, Payet C, OSiorain J, et al.
Nat Commun
. 2022 Dec;
13(1):7217.
PMID: 36470865
Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many aspects of immunity; however,...
4.
OSiorain J, Curtis A
Antioxid Redox Signal
. 2022 Feb;
37(10-12):664-678.
PMID: 35166129
Macrophages are immune sentinels located throughout the body that function in both amplification and resolution of the inflammatory response. The circadian clock has emerged as a central regulator of macrophage...
5.
Cox S, OSiorain J, Fagan L, Curtis A, Carroll R
Semin Immunopathol
. 2022 Jan;
44(2):225-237.
PMID: 35022891
It has emerged that an interconnected relationship exists between metabolism, circadian rhythms, and the immune system. The relationship between metabolism and circadian rhythms is not that surprising given the necessity...
6.
Timmons G, Carroll R, OSiorain J, Cervantes-Silva M, Fagan L, Cox S, et al.
Front Immunol
. 2021 Dec;
12:700431.
PMID: 34858390
The transcription factor BMAL1 is a clock protein that generates daily or circadian rhythms in physiological functions including the inflammatory response of macrophages. Intracellular metabolic pathways direct the macrophage inflammatory...
7.
Collins E, Cervantes-Silva M, Timmons G, OSiorain J, Curtis A, Hurley J
Genome Res
. 2021 Jan;
31(2):171-185.
PMID: 33436377
Our core timekeeping mechanism, the circadian clock, plays a vital role in immunity. Although the mechanics of circadian control over the immune response is generally explained by transcriptional activation or...
8.
Timmons G, OSiorain J, Kennedy O, Curtis A, Early J
Front Immunol
. 2020 Aug;
11:1743.
PMID: 32849621
The circadian cycle allows organisms to track external time of day and predict/respond to changes in the external environment. In higher order organisms, circadian rhythmicity is a central feature of...