George A Timmons
Overview
Explore the profile of George A Timmons including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
143
Followers
0
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Recent Articles
1.
Cervantes-Silva M, Carroll R, Wilk M, Moreira D, Payet C, OSiorain J, et al.
Nat Commun
. 2022 Dec;
13(1):7217.
PMID: 36470865
Dendritic cells play a key role in processing and presenting antigens to naïve T cells to prime adaptive immunity. Circadian rhythms are known to regulate many aspects of immunity; however,...
2.
Timmons G, Carroll R, OSiorain J, Cervantes-Silva M, Fagan L, Cox S, et al.
Front Immunol
. 2021 Dec;
12:700431.
PMID: 34858390
The transcription factor BMAL1 is a clock protein that generates daily or circadian rhythms in physiological functions including the inflammatory response of macrophages. Intracellular metabolic pathways direct the macrophage inflammatory...
3.
Collins E, Cervantes-Silva M, Timmons G, OSiorain J, Curtis A, Hurley J
Genome Res
. 2021 Jan;
31(2):171-185.
PMID: 33436377
Our core timekeeping mechanism, the circadian clock, plays a vital role in immunity. Although the mechanics of circadian control over the immune response is generally explained by transcriptional activation or...
4.
Timmons G, OSiorain J, Kennedy O, Curtis A, Early J
Front Immunol
. 2020 Aug;
11:1743.
PMID: 32849621
The circadian cycle allows organisms to track external time of day and predict/respond to changes in the external environment. In higher order organisms, circadian rhythmicity is a central feature of...
5.
Carroll R, Timmons G, Cervantes-Silva M, Kennedy O, Curtis A
Trends Mol Med
. 2019 Jun;
25(7):612-625.
PMID: 31153819
Almost every cell has a molecular clock, which controls gene expression on a 24-h cycle, providing circadian rhythmicity. An example of a circadian behaviour common to most organisms is the...