James R Lokensgard
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Explore the profile of James R Lokensgard including associated specialties, affiliations and a list of published articles.
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68
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2565
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Recent Articles
1.
Fanunza E, Cheng A, Auerbach A, Stefanovska B, Moraes S, Lokensgard J, et al.
J Virol
. 2023 Aug;
97(8):e0078123.
PMID: 37565748
The APOBEC3 family of DNA cytosine deaminases comprises an important arm of the innate antiviral defense system. The gamma-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus and the alpha-herpesviruses herpes simplex...
2.
Prasad S, Singh A, Hu S, Sheng W, Chauhan P, Lokensgard J
iScience
. 2023 May;
26(5):106628.
PMID: 37192971
This study was undertaken to investigate the role of CD4+FoxP3+ regulatory T cells (Tregs) in regulating neuroinflammation during viral Ag-challenge and re-challenge. CD8 lymphocytes persisting within tissues are designated tissue-resident...
3.
Fanunza E, Cheng A, Auerbach A, Stefanovska B, Moraes S, Lokensgard J, et al.
bioRxiv
. 2023 Feb;
PMID: 36778493
Importance: Human cytomegalovirus (HCMV) infections can range from asymptomatic to severe, particularly in neonates and immunocompromised patients. HCMV has evolved strategies to overcome host-encoded antiviral defenses in order to achieve...
4.
Chauhan P, Hu S, Sheng W, Lokensgard J
Cells
. 2022 Sep;
11(18).
PMID: 36139401
Regulatory T-cells (Tregs) play pivotal roles during infection, cancer, and autoimmunity. In our previous study, we demonstrated a role for the PD-1:PD-L1 pathway in controlling cytolytic responses of CD8 T...
5.
Chauhan P, Sheng W, Hu S, Prasad S, Lokensgard J
Brain Sci
. 2021 Nov;
11(11).
PMID: 34827481
The role of select pro- and anti-inflammatory mediators in driving microglial cell polarization into classically (M1), or alternatively, (M2) activated states, as well as the subsequent differential responses of these...
6.
Prasad S, Sheng W, Hu S, Chauhan P, Lokensgard J
Front Cell Neurosci
. 2021 Aug;
15:686340.
PMID: 34447297
Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bT) may respond to -produced viral Ag through the rapid release of IFN-γ, which drives subsequent interferon-stimulated gene...
7.
Chauhan P, Hu S, Prasad S, Sheng W, Lokensgard J
Glia
. 2020 Oct;
69(4):858-871.
PMID: 33128485
Microglial cells are the main reservoir for HIV-1 within the brain and potential exists for negative immune checkpoint blockade therapies to purge this viral reservoir. Here, we investigated cytolytic responses...
8.
Fernandez-Alarcon C, Meyer L, McVoy M, Lokensgard J, Hu S, Benneyworth M, et al.
Pediatr Res
. 2020 Jun;
89(4):838-845.
PMID: 32555536
Background: Cytomegalovirus (CMV) is a leading infectious cause of neurologic deficits, both in the settings of congenital and perinatal infection, but few animal models exist to study neurodevelopmental outcomes. This...
9.
Prasad S, Hu S, Sheng W, Chauhan P, Lokensgard J
iScience
. 2019 Oct;
20:512-526.
PMID: 31655062
HIV-associated neurocognitive disorders (HAND) persist even during effective combination antiretroviral therapy (cART). Although the cause of HAND is unknown, studies link chronic immune activation, neuroinflammation, and cerebrospinal fluid viral escape...
10.
Sheng W, Chauhan P, Hu S, Prasad S, Lokensgard J
Pain Res Manag
. 2019 Jul;
2019:1260353.
PMID: 31354896
The most common neurological complication in patients receiving successful combination antiretroviral therapy (cART) is peripheral neuropathic pain. Data show that distal symmetric polyneuropathy (DSP) also develops along with murine acquired...