James R Doroghazi
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Explore the profile of James R Doroghazi including associated specialties, affiliations and a list of published articles.
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27
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1068
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Recent Articles
11.
Doroghazi J, Buckley D
BMC Genomics
. 2014 Nov;
15:970.
PMID: 25399205
Background: Streptomyces are widespread bacteria that contribute to the terrestrial carbon cycle and produce the majority of clinically useful antibiotics. While interspecific genomic diversity has been investigated among Streptomyces, information...
12.
Doroghazi J, Albright J, Goering A, Ju K, Haines R, Tchalukov K, et al.
Nat Chem Biol
. 2014 Sep;
10(11):963-8.
PMID: 25262415
Actinobacteria encode a wealth of natural product biosynthetic gene clusters, whose systematic study is complicated by numerous repetitive motifs. By combining several metrics, we developed a method for the global...
13.
Cox C, Tietz J, Sokolowski K, Melby J, Doroghazi J, Mitchell D
ACS Chem Biol
. 2014 Jun;
9(9):2014-22.
PMID: 24937678
Natural products remain an important source of drug candidates, but the difficulties inherent to traditional isolation, coupled with unacceptably high rates of compound rediscovery, limit the pace of natural product...
14.
Cioni J, Doroghazi J, Ju K, Yu X, Evans B, Lee J, et al.
J Nat Prod
. 2014 Jan;
77(2):243-9.
PMID: 24437999
Streptomyces regensis strain WC-3744 was identified as a potential phosphonic acid producer in a large-scale screen of microorganisms for the presence of the pepM gene, which encodes the key phosphonate...
15.
Gao J, Ju K, Yu X, Velasquez J, Mukherjee S, Lee J, et al.
Angew Chem Int Ed Engl
. 2013 Dec;
53(5):1334-7.
PMID: 24376039
Natural product discovery has been boosted by genome mining approaches, but compound purification is often still challenging. We report an enzymatic strategy for "stable isotope labeling of phosphonates in extract"...
16.
Yu X, Doroghazi J, Janga S, Zhang J, Circello B, Griffin B, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
110(51):20759-64.
PMID: 24297932
Phosphonates, molecules containing direct carbon-phosphorus bonds, compose a structurally diverse class of natural products with interesting and useful biological properties. Although their synthesis in protozoa was discovered more than 50...
17.
Ju K, Doroghazi J, Metcalf W
J Ind Microbiol Biotechnol
. 2013 Nov;
41(2):345-56.
PMID: 24271089
Phosphonate natural products have proven to be a rich source of useful pharmaceutical, agricultural, and biotechnology products, whereas study of their biosynthetic pathways has revealed numerous intriguing enzymes that catalyze...
18.
Albright J, Goering A, Doroghazi J, Metcalf W, Kelleher N
J Ind Microbiol Biotechnol
. 2013 Nov;
41(2):451-9.
PMID: 24242000
The use of proteomics for direct detection of expressed pathways producing natural products has yielded many new compounds, even when used in a screening mode without a bacterial genome sequence...
19.
Doroghazi J, Metcalf W
BMC Genomics
. 2013 Sep;
14:611.
PMID: 24020438
Background: Actinomycetes are a diverse group of medically, industrially and ecologically important bacteria, studied as much for the diseases they cause as for the cures they hold. The genomes of...
20.
Rong X, Doroghazi J, Cheng K, Zhang L, Buckley D, Huang Y
Syst Appl Microbiol
. 2013 Jun;
36(6):401-7.
PMID: 23769815
The Streptomyces phylogroup pratensis (Doroghazi and Buckley, 2010) contains isolates obtained from grassy fields, as well as Streptomyces flavogriseus ATCC 33331 and strain CGMCC 4.1868. This latter strain was received...