James P Stewart
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Explore the profile of James P Stewart including associated specialties, affiliations and a list of published articles.
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Articles
114
Citations
3174
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Recent Articles
21.
Neary M, Sharp J, Gallardo-Toledo E, Herriott J, Kijak E, Bramwell C, et al.
Viruses
. 2023 Aug;
15(8).
PMID: 37632086
The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2...
22.
De Neck S, Penrice-Randal R, Clark J, Sharma P, Bentley E, Kirby A, et al.
Viruses
. 2023 Aug;
15(8).
PMID: 37631979
The respiratory system is the main target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 19 (COVID-19) where acute respiratory distress syndrome is considered the...
23.
Han X, Clark J, Sharma P, Bentley E, Kipar A, Alsayer M, et al.
Virology
. 2023 Jul;
587:109849.
PMID: 37515945
Myosin heavy chain 9 (MYH9) has been identified as a crucial factor in gammaherpesvirus infection. Murine gammaherpesvirus 68 (MHV-68) was used as an appropriate viral model for investigating gammaherpesviruses in...
24.
Gaynor K, Vaysburd M, Harman M, Albecka A, Jeffrey P, Beswick P, et al.
Nat Commun
. 2023 Jun;
14(1):3583.
PMID: 37328472
COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of...
25.
Roddy A, McInerney C, Flannery T, Healy E, Stewart J, Spence V, et al.
Biomedicines
. 2023 May;
11(4).
PMID: 37189838
Glioblastoma (GBM) is the most prevalent and aggressive adult brain tumor. Despite multi-modal therapies, GBM recurs, and patients have poor survival (~14 months). Resistance to therapy may originate from a...
26.
Wang Y, Ramos M, Jefferson M, Zhang W, Beraza N, Carding S, et al.
Sci Adv
. 2022 Oct;
8(43):eabn3298.
PMID: 36288298
The delivery of pathogens to lysosomes for degradation provides an important defense against infection. Degradation is enhanced when LC3 is conjugated to endosomes and phagosomes containing pathogens to facilitate fusion...
27.
Gai D, Chen J, Stewart J, Nookaew I, Habelhah H, Ashby C, et al.
J Clin Invest
. 2022 Jul;
132(18).
PMID: 35881476
Osteolytic bone disease is a hallmark of multiple myeloma (MM). A significant fraction (~20%) of MM patients do not develop osteolytic lesions (OLs). The molecular basis for the absence of...
28.
Kamioka N, Greenbaum A, Lederman R, Khan J, Lisko J, Byku I, et al.
Cardiovasc Revasc Med
. 2022 Jul;
53S:S176-S179.
PMID: 35879191
A cardiogenic shock patient with a history of a surgical mitral valve replacement presented to the hospital with critical mitral stenosis with thickening of prosthetic valve leaflets and thrombus in...
29.
Dong X, Penrice-Randal R, Goldswain H, Prince T, Randle N, Donovan-Banfield I, et al.
Gigascience
. 2022 May;
11.
PMID: 35639883
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a complex strategy for the transcription of viral subgenomic mRNAs (sgmRNAs), which are targets for nucleic acid diagnostics. Each of these sgmRNAs...
30.
Seehusen F, Clark J, Sharma P, Bentley E, Kirby A, Subramaniam K, et al.
Viruses
. 2022 May;
14(5).
PMID: 35632761
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) not only affects the respiratory tract but also causes neurological symptoms such as loss of smell and taste, headache, fatigue or severe cerebrovascular...