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James McNally

Explore the profile of James McNally including associated specialties, affiliations and a list of published articles. Areas
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Articles 27
Citations 961
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Recent Articles
1.
Wustner D, Juhl A, Egebjerg J, Werner S, McNally J, Schneider G
Front Cell Dev Biol . 2023 Nov; 11:1144936. PMID: 38020900
Niemann Pick type C1 and C2 (NPC1 and NPC2) are two sterol-binding proteins which, together, orchestrate cholesterol transport through late endosomes and lysosomes (LE/LYSs). NPC2 can facilitate sterol exchange between...
2.
Dyhr M, Sadeghi M, Moynova R, Knappe C, Kepsutlu Cakmak B, Werner S, et al.
Proc Natl Acad Sci U S A . 2023 Jun; 120(24):e2209938120. PMID: 37276395
Cryo-soft X-ray tomography (cryo-SXT) is a powerful method to investigate the ultrastructure of cells, offering resolution in the tens of nanometer range and strong contrast for membranous structures without requiring...
3.
Juhl A, Lund F, Jensen M, Szomek M, Heegaard C, Guttmann P, et al.
Chem Phys Lipids . 2021 Jan; 235:105047. PMID: 33422548
The Niemann-Pick C2 protein (NPC2) is a sterol transfer protein in the lumen of late endosomes and lysosomes (LE/LYSs). Absence of functional NPC2 leads to endo-lysosomal buildup of cholesterol and...
4.
Megna B, Carney P, Depke M, Nukaya M, McNally J, Larsen L, et al.
J Surg Res . 2017 Jun; 213:16-24. PMID: 28601309
Background: Curcumin has proven to be a potent antitumor agent in both preclinical and clinical models of colorectal cancer (CRC). It has also been identified as a ligand of the...
5.
Zant J, Kim T, Prokai L, Szarka S, McNally J, McKenna J, et al.
J Neurosci . 2016 Feb; 36(6):2057-67. PMID: 26865627
Significance Statement: Optogenetics is a revolutionary tool to assess the roles of particular groups of neurons in behavioral functions, such as control of sleep and wakefulness. However, the interpretation of...
6.
Leal M, Wentland J, Han X, Zhang Y, Rago B, Duriga N, et al.
Bioconjug Chem . 2015 Jul; 26(11):2223-32. PMID: 26180901
The pharmacokinetics of an antibody (huA1)-drug (auristatin microtubule disrupting MMAF) conjugate, targeting 5T4-expressing cells, were characterized during the discovery and development phases in female nu/nu mice and cynomolgus monkeys after...
7.
Hurley A, Smith M, Karpova T, Hasley R, Belkina N, Shaw S, et al.
J Infect Dis . 2012 Dec; 207(4):638-50. PMID: 23204166
Disruption of vascular integrity by trauma and other tissue insults leads to inflammation and activation of the coagulation cascade. The serine protease thrombin links these 2 processes. The proinflammatory function...
8.
Panapasa S, Jackson J, Caldwell C, Heeringa S, McNally J, Williams D, et al.
Prog Community Health Partnersh . 2012 May; 6(1):53-8. PMID: 22643788
Objectives: Reports on the challenges and lessons learned from the Pacific Island American Health Study engagement with community-based organizations (CBOs) and faith-based organizations (FBOs) in Pacific Islander (PI) communities and...
9.
Gordon S, Cecchinato V, Andresen V, Heraud J, Hryniewicz A, Washington Parks R, et al.
J Infect Dis . 2011 Apr; 203(8):1043-53. PMID: 21450994
The licensed smallpox vaccine, ACAM2000, is a cell culture derivative of Dryvax. Both ACAM2000 and Dryvax are administered by skin scarification and can cause progressive vaccinia, with skin lesions that...
10.
Dey A, Nishiyama A, Karpova T, McNally J, Ozato K
Mol Biol Cell . 2009 Oct; 20(23):4899-909. PMID: 19812244
On entry into mitosis, many transcription factors dissociate from chromatin, resulting in global transcriptional shutdown. During mitosis, some genes are marked to ensure the inheritance of their expression in the...