James McKerrow
Overview
Explore the profile of James McKerrow including associated specialties, affiliations and a list of published articles.
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23
Citations
368
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0
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Recent Articles
1.
Maltarollo V, Barbosa da Silva E, Kronenberger T, Sena Andrade M, de Lima Marques G, Candido Oliveira N, et al.
Future Med Chem
. 2023 Jul;
15(11):959-985.
PMID: 37435731
Discovery of novel SARS-CoV-2 main protease (M) inhibitors using a structure-based drug discovery strategy. Virtual screening employing covalent and noncovalent docking was performed to discover M inhibitors, which were subsequently...
2.
Barbosa da Silva E, Rocha D, Fortes I, Yang W, Monti L, Siqueira-Neto J, et al.
J Med Chem
. 2021 Aug;
64(17):13054-13071.
PMID: 34461718
The cysteine proteases, cruzain and CATL (rhodesain), are therapeutic targets for Chagas disease and Human African Trypanosomiasis, respectively. Among the known inhibitors for these proteases, we have described -benzyl--phenylquinazoline-2,4-diamine (compound...
3.
Al-Obeed O, El-Obeid A, Matou-Nasri S, Vaali-Mohammed M, Alhaidan Y, Elwatidy M, et al.
Cancer Cell Int
. 2020 Apr;
20:126.
PMID: 32322173
Background: Colorectal carcinoma is one of the most deadly cancers that requests effective and safe chemotherapy. Evaluation of natural product-based anticancer drugs as adjuvant treatment with fewer side effects is...
4.
Singh B, Bernatchez J, McCall L, Calvet C, Ackermann J, Souza J, et al.
ACS Med Chem Lett
. 2020 Mar;
11(3):249-257.
PMID: 32184953
Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against , plus 31 new compounds, against a variety of protozoan parasites...
5.
Akama T, Freund Y, Berry P, Carter D, Easom E, Jarnagin K, et al.
ACS Infect Dis
. 2019 Dec;
6(2):173-179.
PMID: 31876154
A series of benzimidazole-benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good activity against , a filarial nematode responsible for the disease onchocerciasis, also known as...
6.
Carter D, Jacobs R, Freund Y, Berry P, Akama T, Easom E, et al.
ACS Infect Dis
. 2019 Dec;
6(2):180-185.
PMID: 31876143
The optimization of a series of benzimidazole-benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against , a filarial nematode responsible for the disease onchocerciasis, also known as...
7.
Abdulla M, Valli-Mohammed M, Al-Khayal K, Al Shkieh A, Zubaidi A, Ahmad R, et al.
Oncol Rep
. 2017 Apr;
37(6):3175-3180.
PMID: 28440429
Cathepsin B (CTSB), is a cysteine protease belonging to the cathepsin (Clan CA) family. The diagnostic and prognostic significance of increased CTSB in the serum of cancer patients have been...
8.
De Muylder G, Vanhollebeke B, Caljon G, Wolfe A, McKerrow J, Dujardin J
PLoS Negl Trop Dis
. 2016 Dec;
10(12):e0005234.
PMID: 28036391
Host-directed therapies (HDTs) constitute promising alternatives to traditional therapy that directly targets the pathogen but is often hampered by pathogen resistance. HDT could represent a new treatment strategy for leishmaniasis,...
9.
Bieler S, Waltenberger H, Barrett M, McCulloch R, Mottram J, Carrington M, et al.
PLoS One
. 2016 Dec;
11(12):e0168074.
PMID: 27936225
Background: Control and elimination of human African trypanosomiasis (HAT) can be accelerated through the use of diagnostic tests that are more accurate and easier to deploy. The goal of this...
10.
Hamadien M, Khan Z, Vaali-Mohammed M, Zubaidi A, Al-Khayal K, McKerrow J, et al.
Tumour Biol
. 2015 Nov;
37(4):5529-37.
PMID: 26572151
Tumor necrosis factor-alpha (TNF-α) contributes in inflammation and has been implicated in the development of colorectal cancer (CRC). Single nucleotide polymorphisms (SNPs) in TNF-α promoter could affect the risk of...