James Manfredi
Overview
Explore the profile of James Manfredi including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
185
Followers
0
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Recent Articles
1.
Pappas K, Xu J, Zairis S, Resnick-Silverman L, Abate F, Steinbach N, et al.
Mol Cancer Res
. 2017 May;
15(8):1051-1062.
PMID: 28483946
is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not...
2.
Laptenko O, Tong D, Manfredi J, Prives C
Trends Biochem Sci
. 2016 Sep;
41(12):1022-1034.
PMID: 27669647
The p53 tumor suppressor is a transcription factor (TF) that exerts antitumor functions through its ability to regulate the expression of multiple genes. Within the p53 protein resides a relatively...
3.
Li T, Liu X, Jiang L, Manfredi J, Zha S, Gu W
Oncotarget
. 2016 Mar;
7(11):11838-49.
PMID: 26943586
Although p53-mediated cell cycle arrest, senescence and apoptosis are well accepted as major tumor suppression mechanisms, the loss of these functions does not directly lead to tumorigenesis, suggesting that the...
4.
Laptenko O, Shiff I, Freed-Pastor W, Zupnick A, Mattia M, Freulich E, et al.
Mol Cell
. 2015 Mar;
57(6):1034-1046.
PMID: 25794615
DNA binding by numerous transcription factors including the p53 tumor suppressor protein constitutes a vital early step in transcriptional activation. While the role of the central core DNA binding domain...
5.
Torti F, Altieri D, Broach J, Fan H, Lotze M, Manfredi J, et al.
Cancer Res
. 2008 Nov;
68(22):9122-4.
PMID: 19010881
No abstract available.