James M Park
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Explore the profile of James M Park including associated specialties, affiliations and a list of published articles.
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8
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155
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Recent Articles
1.
Zhu Q, Mishra A, Park J, Liu D, Le D, Gonzalez S, et al.
Neuron
. 2023 Jan;
111(6):807-823.e7.
PMID: 36626901
Previously, we demonstrated the efficacy of human pluripotent stem cell (hPSC)-derived GABAergic cortical interneuron (cIN) grafts in ameliorating seizures. However, a safe and reliable clinical translation requires a mechanistic understanding...
2.
Liu D, Zinski A, Mishra A, Noh H, Park G, Qin Y, et al.
Mol Psychiatry
. 2022 Jun;
27(10):4218-4233.
PMID: 35701597
Remarkable advances have been made in schizophrenia (SCZ) GWAS, but gleaning biological insight from these loci is challenging. Genetic influences on gene expression (e.g., eQTLs) are cell type-specific, but most...
3.
Park J, Liu D, Park G, Noh H, Ni P, Yin C, et al.
J Psychiatr Res
. 2021 Mar;
137:111-116.
PMID: 33677214
Cortical interneurons (cINs) are substantially affected in Schizophrenia (SCZ) and enriched for SCZ heritability during development. To understand SCZ-specific changes in these cells during development, we isolated migratory cINs from...
4.
Park G, Noh H, Shao Z, Ni P, Qin Y, Liu D, et al.
Nat Neurosci
. 2020 Oct;
23(11):1352-1364.
PMID: 33097921
The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical interneurons (cINs)-which are known to be affected in schizophrenia (SCZ)...
5.
Ni P, Noh H, Park G, Shao Z, Guan Y, Park J, et al.
Mol Psychiatry
. 2019 Aug;
25(11):3103-3104.
PMID: 31366918
A correction to this paper has been published and can be accessed via a link at the top of the paper.
6.
Ni P, Noh H, Shao Z, Zhu Q, Guan Y, Park J, et al.
Mol Ther Methods Clin Dev
. 2019 May;
13:414-430.
PMID: 31061832
During development, cortical interneurons (cINs) are generated from the ventral telencephalon, robustly migrate to the dorsal telencephalon, make local synaptic connections, and critically regulate brain circuitry by inhibiting other neurons....
7.
Ni P, Noh H, Park G, Shao Z, Guan Y, Park J, et al.
Mol Psychiatry
. 2019 Apr;
25(11):2873-2888.
PMID: 31019265
Schizophrenia (SCZ) is a neurodevelopmental disorder. Thus, studying pathogenetic mechanisms underlying SCZ requires studying the development of brain cells. Cortical interneurons (cINs) are consistently observed to be abnormal in SCZ...
8.
Shao Z, Noh H, Kim W, Ni P, Nguyen C, Cote S, et al.
Nat Neurosci
. 2019 Jan;
22(2):229-242.
PMID: 30664768
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired...