James M Hogle
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Explore the profile of James M Hogle including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
2024
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Recent Articles
1.
Kingston N, Snowden J, Grehan K, Hall P, Hietanen E, Passchier T, et al.
PLoS Pathog
. 2024 Sep;
20(9):e1012511.
PMID: 39298524
Molecular details of genome packaging are little understood for the majority of viruses. In enteroviruses (EVs), cleavage of the structural protein VP0 into VP4 and VP2 is initiated by the...
2.
Shankar S, Pan J, Yang P, Bian Y, Oroszlan G, Yu Z, et al.
Cell
. 2024 Aug;
187(20):5572-5586.e15.
PMID: 39197451
DNA polymerases are important drug targets, and many structural studies have captured them in distinct conformations. However, a detailed understanding of the impact of polymerase conformational dynamics on drug resistance...
3.
Kingston N, Snowden J, Grehan K, Hall P, Hietanen E, Passchier T, et al.
bioRxiv
. 2024 Apr;
PMID: 38617325
Molecular details of genome packaging are little understood for the majority of viruses. In enteroviruses (EVs), cleavage of the structural protein VP0 into VP4 and VP2 is initiated by the...
4.
Chen H, Lye M, Gorgulla C, Ficarro S, Cuny G, Scott D, et al.
PLoS Pathog
. 2023 Nov;
19(11):e1011781.
PMID: 37976321
Human cytomegalovirus (HCMV) is an important pathogen for which new antiviral drugs are needed. HCMV, like other herpesviruses, encodes a nuclear egress complex (NEC) composed of two subunits, UL50 and...
5.
Kingston N, Snowden J, Martyna A, Shegdar M, Grehan K, Tedcastle A, et al.
J Gen Virol
. 2023 Jun;
104(6).
PMID: 37390009
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral...
6.
Kingston N, Snowden J, Martyna A, Shegdar M, Grehan K, Tedcastle A, et al.
bioRxiv
. 2023 Feb;
PMID: 36778240
Enterovirus A71 (EVA71) causes widespread disease in young children with occasional fatal consequences. In common with other picornaviruses, both empty capsids (ECs) and infectious virions are produced during the viral...
7.
Karunatilaka K, Filman D, Strauss M, Loparo J, Hogle J
mBio
. 2021 Feb;
12(1).
PMID: 33622727
Genome transfer from a virus into a cell is a critical early step in viral replication. Enveloped viruses achieve the delivery of their genomes into the cytoplasm by merging the...
8.
Chen H, Lawler J, Filman D, Hogle J, Coen D
mBio
. 2021 Feb;
12(1).
PMID: 33563814
Nucleoside analogs are mainstays of antiviral therapy. Although resistance to these drugs hinders their use, understanding resistance can illuminate mechanisms of the drugs and their targets. Certain nucleoside analogs, such...
9.
Shah P, Filman D, Karunatilaka K, Hesketh E, Groppelli E, Strauss M, et al.
PLoS Pathog
. 2020 Sep;
16(9):e1008920.
PMID: 32997730
The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at...
10.
Zhao Z, Zhang M, Hogle J, Shih W, Wagner G, Nasr M
J Am Chem Soc
. 2018 Aug;
140(34):10639-10643.
PMID: 30094995
Here we present a modular method for manufacturing large-sized nanodiscs using DNA-origami barrels as scaffolding corrals. Large-sized nanodiscs can be produced by first decorating the inside of DNA barrels with...