James M Eldred
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Explore the profile of James M Eldred including associated specialties, affiliations and a list of published articles.
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9
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2813
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Recent Articles
1.
Larson D, Abel H, Chiang C, Badve A, Das I, Eldred J, et al.
Bioinformatics
. 2019 Jun;
35(22):4782-4787.
PMID: 31218349
Summary: Large-scale human genetics studies are now employing whole genome sequencing with the goal of conducting comprehensive trait mapping analyses of all forms of genome variation. However, methods for structural...
2.
Griffith M, Spies N, Krysiak K, McMichael J, Coffman A, Danos A, et al.
Nat Genet
. 2017 Feb;
49(2):170-174.
PMID: 28138153
No abstract available.
3.
Griffith M, Griffith O, Krysiak K, Skidmore Z, Christopher M, Klco J, et al.
Exp Hematol
. 2016 May;
44(7):603-13.
PMID: 27181063
The genomic events responsible for the pathogenesis of relapsed adult B-lymphoblastic leukemia (B-ALL) are not yet clear. We performed integrative analysis of whole-genome, whole-exome, custom capture, whole-transcriptome (RNA-seq), and locus-specific...
4.
Lu C, Xie M, Wendl M, Wang J, McLellan M, Leiserson M, et al.
Nat Commun
. 2015 Dec;
6:10086.
PMID: 26689913
Large-scale cancer sequencing data enable discovery of rare germline cancer susceptibility variants. Here we systematically analyse 4,034 cases from The Cancer Genome Atlas cancer cases representing 12 cancer types. We...
5.
Wagner A, Coffman A, Ainscough B, Spies N, Skidmore Z, Campbell K, et al.
Nucleic Acids Res
. 2015 Nov;
44(D1):D1036-44.
PMID: 26531824
The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that consolidates disparate data sources describing drug-gene interactions and gene druggability. It provides an intuitive graphical user interface and a...
6.
Griffith M, Griffith O, Smith S, Ramu A, Callaway M, Brummett A, et al.
PLoS Comput Biol
. 2015 Jul;
11(7):e1004274.
PMID: 26158448
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides...
7.
Griffith M, Griffith O, Coffman A, Weible J, McMichael J, Spies N, et al.
Nat Methods
. 2013 Oct;
10(12):1209-10.
PMID: 24122041
The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching...
8.
Ding L, Ellis M, Li S, Larson D, Chen K, Wallis J, et al.
Nature
. 2010 Apr;
464(7291):999-1005.
PMID: 20393555
Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples...
9.
Mardis E, Ding L, Dooling D, Larson D, McLellan M, Chen K, et al.
N Engl J Med
. 2009 Aug;
361(11):1058-66.
PMID: 19657110
Background: The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known. Methods: We used massively parallel DNA sequencing to...