James M Eales
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Explore the profile of James M Eales including associated specialties, affiliations and a list of published articles.
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16
Citations
303
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Recent Articles
1.
Kelly J, Xu X, Eales J, Keavney B, Berzuini C, Tomaszewski M, et al.
BMC Med Res Methodol
. 2024 Aug;
24(1):168.
PMID: 39095705
Background: Understanding the complex interactions between genes and their causal effects on diseases is crucial for developing targeted treatments and gaining insight into biological mechanisms. However, the analysis of molecular...
2.
Xu X, Khunsriraksakul C, Eales J, Rubin S, Scannali D, Saluja S, et al.
Nat Commun
. 2024 Mar;
15(1):2359.
PMID: 38504097
Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of...
3.
Tomaszewski M, Morris A, Howson J, Franceschini N, Eales J, Xu X, et al.
Kidney Int
. 2022 Jun;
102(3):492-505.
PMID: 35690124
Hypertension is a major cardiovascular disease risk factor and contributor to premature death globally. Family-based investigations confirmed a significant heritable component of blood pressure (BP), whereas genome-wide association studies revealed...
4.
Xu X, Eales J, Jiang X, Sanderson E, Drzal M, Saluja S, et al.
Cardiovasc Res
. 2021 Dec;
118(15):3151-3161.
PMID: 34893803
Aims: Obesity and kidney diseases are common complex disorders with an increasing clinical and economic impact on healthcare around the globe. Our objective was to examine if modifiable anthropometric obesity...
5.
Matias-Garcia P, Wilson R, Guo Q, Zaghlool S, Eales J, Xu X, et al.
J Am Soc Nephrol
. 2021 Jun;
32(7):1747-1763.
PMID: 34135082
Background: Studies on the relationship between renal function and the human plasma proteome have identified several potential biomarkers. However, investigations have been conducted largely in European populations, and causality of...
6.
Eales J, Jiang X, Xu X, Saluja S, Akbarov A, Cano-Gamez E, et al.
Nat Genet
. 2021 May;
53(5):630-637.
PMID: 33958779
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and antihypertensive treatment. However, genetically mediated renal mechanisms underlying susceptibility to hypertension remain poorly understood. We...
7.
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Breeze C, Batorsky A, Lee M, Szeto M, Xu X, McCartney D, et al.
Genome Med
. 2021 May;
13(1):74.
PMID: 33931109
Background: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African...
8.
Surendran P, Feofanova E, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, et al.
Nat Genet
. 2021 Mar;
53(5):762.
PMID: 33727701
No abstract available.
9.
Surendran P, Feofanova E, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, et al.
Nat Genet
. 2020 Nov;
52(12):1314-1332.
PMID: 33230300
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106...
10.
Jiang X, Eales J, Scannali D, Nazgiewicz A, Prestes P, Maier M, et al.
Eur Heart J
. 2020 Nov;
41(48):4580-4588.
PMID: 33206176
Aims: Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)-the cause of coronavirus disease 2019 (COVID-19). However, the effect of renin-angiotensin system (RAS)-inhibition...