James M Cunningham
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Explore the profile of James M Cunningham including associated specialties, affiliations and a list of published articles.
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23
Citations
1284
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Recent Articles
1.
Valderrabano R, Wipper B, Pencina K, Migaud M, Shang Y, Latham N, et al.
Aging Cell
. 2024 Oct;
23(12):e14326.
PMID: 39354697
Nicotinamide adenine dinucleotide (NAD) depletion has been postulated as a contributor to the severity of COVID-19; however, no study has prospectively characterized NAD and its metabolites in relation to disease...
2.
Beitzel B, Radoshitzky S, Di Paola N, Brannan J, Kimmel D, Caviness K, et al.
Viruses
. 2021 Oct;
13(10).
PMID: 34696439
Biosafety, biosecurity, logistical, political, and technical considerations can delay or prevent the wide dissemination of source material containing viable virus from the geographic origin of an outbreak to laboratories involved...
3.
Cote M, Cunningham J
Virologie (Montrouge)
. 2020 Oct;
16(3):168-177.
PMID: 33065873
Ebola and Marburg viruses cause outbreaks of highly lethal infection in central Africa. In the last few years, rapid progress has been made in understanding how these viruses are transmitted...
4.
Kulyk K, Azizova L, Cunningham J, Mikhalovska L, Borysenko M, Mikhalovsky S
J Mater Chem B
. 2020 Apr;
8(19):4267-4277.
PMID: 32301952
Nitric oxide NO, mediates inflammatory and thrombotic processes and designing biomaterials capable of releasing NO in contact with biological tissues is considered to be a major factor aimed at improving...
5.
Sivakumaren S, Shim H, Zhang T, Ferguson F, Lundquist M, Browne C, et al.
Cell Chem Biol
. 2020 Mar;
27(5):525-537.e6.
PMID: 32130941
The PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these kinases is understudied due to a lack of...
6.
Wang M, Ren T, Liu H, Lim S, Lee K, Honko A, et al.
PLoS Pathog
. 2018 Sep;
14(9):e1007322.
PMID: 30265711
Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor of LASV and used it to...
7.
Liu H, Tian Y, Lee K, Krishnan P, Wang M, Whelan S, et al.
J Med Chem
. 2018 Jun;
61(14):6293-6307.
PMID: 29920098
Previous studies identified an adamantane dipeptide piperazine 3.47 that inhibits Ebola virus (EBOV) infection by targeting the essential receptor Niemann-Pick C1 (NPC1). The physicochemical properties of 3.47 limit its potential...
8.
Wang M, Lim S, Lee S, Cunningham J
Cell Host Microbe
. 2017 Feb;
21(3):367-375.
PMID: 28238624
Ebola virus (EBOV) infection is characterized by sporadic outbreaks caused by zoonotic transmission. Fixed changes in amino acid sequence, such as A82V in the EBOV glycoprotein (GP) that occurred early...
9.
Alessa M, Craig A, Cunningham J
Am J Case Rep
. 2015 Sep;
16:590-3.
PMID: 26334783
Background: Rasburicase is a recombinant urate oxidase enzyme that converts uric acid to allantoin (an inactive and soluble metabolite that is readily excreted in urine). It is used for the...
10.
Eltoukhy A, Sahay G, Cunningham J, Anderson D
ACS Nano
. 2014 Jul;
8(8):7905-13.
PMID: 25010491
Despite intensive research effort, the rational design of improved nanoparticulate drug carriers remains challenging, in part due to a limited understanding of the determinants of nanoparticle entry and transport in...