James L Krahenbuhl
Overview
Explore the profile of James L Krahenbuhl including associated specialties, affiliations and a list of published articles.
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15
Citations
232
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Recent Articles
1.
Davis G, Ray N, Lahiri R, Gillis T, Krahenbuhl J, Williams D, et al.
PLoS Negl Trop Dis
. 2013 Nov;
7(8):e2404.
PMID: 24179562
Background: The inability of Mycobacterium leprae to grow on axenic media has necessitated specialized techniques in order to determine viability of this organism. The purpose of this study was to...
2.
Lahiri R, Randhawa B, Franken K, Duthie M, Spencer J, Geluk A, et al.
Lepr Rev
. 2012 Mar;
82(4):432-44.
PMID: 22439282
Early diagnosis of leprosy and a multi-drug therapy (MDT) regimen will block the trajectory of nerve damage, disability and deformity that are the hallmarks of this chronic disease. However, the...
3.
Lahiri R, Randhawa B, Krahenbuhl J
J Infect Dis
. 2010 Apr;
201(11):1736-42.
PMID: 20402595
The role played by apoptosis in host response to Mycobacterium leprae is unclear. Here, we studied in vitro induction of apoptosis in mouse bone marrow-derived macrophages infected with live and...
4.
Lahiri R, Krahenbuhl J
Lepr Rev
. 2009 Mar;
79(4):401-9.
PMID: 19274986
Objectives: Leprosy transmission remains poorly understood, though, prolonged skin contact and/or infection via nasal mucosa, are considered likely. Problematic in any transmission hypothesis is the fastidious nature of Mycobacterium leprae...
5.
Hagge D, Saunders B, Ebenezer G, Ray N, Marks V, Britton W, et al.
Am J Pathol
. 2009 Feb;
174(4):1379-89.
PMID: 19246648
Recent studies identified an association between genetic variants in the lymphotoxin-alpha (LTalpha) gene and leprosy. To study the influence of LTalpha on the control of experimental leprosy, both low- and...
6.
Lahiri R, Sandoval F, Krahenbuhl J, Shannon E
Lepr Rev
. 2008 Nov;
79(3):311-4.
PMID: 19009980
Objective: The immune-mediated events that precipitate erythema nodosum leprosum (ENL) are not well understood. One component may be the complexing of antibody with antigens released from infected macrophages, the activation...
7.
Truman R, Andrews P, Robbins N, Adams L, Krahenbuhl J, Gillis T
PLoS Negl Trop Dis
. 2008 Nov;
2(11):e328.
PMID: 18982056
Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We have developed a...
8.
Sousa A, Stefani M, Pereira G, Costa M, Rebello P, Gomes M, et al.
Am J Trop Med Hyg
. 2007 Nov;
77(5):829-33.
PMID: 17984336
Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities. Single skin lesion paucibacillary leprosy volunteers (N = 135) recruited...
9.
Duthie M, Reece S, Lahiri R, Goto W, Raman V, Kaplan J, et al.
Infect Immun
. 2007 Aug;
75(11):5290-7.
PMID: 17724073
Leprosy is caused by infection with Mycobacterium leprae. The immune response of leprosy patients can be highly diverse, ranging from strong cellular responses accompanied by an apparent deficit of M....
10.
Hagge D, Marks V, Ray N, Dietrich M, Kearney M, Scollard D, et al.
FEMS Immunol Med Microbiol
. 2007 Jul;
51(1):92-101.
PMID: 17645529
Cytokine-activated macrophages (MPhi) employ reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) to combat pathogens. The requirement for ROI for an effective host response to experimental leprosy using mice...