James K Liao
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Explore the profile of James K Liao including associated specialties, affiliations and a list of published articles.
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202
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9612
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Recent Articles
1.
Ullah K, Ai L, Li Y, Liu L, Zhang Q, Pan K, et al.
Commun Biol
. 2025 Mar;
8(1):440.
PMID: 40089572
Myocardial infarction (MI) compromises the cardiac microvascular endothelial barrier, increasing leakage and inflammation. HIF2α, predominantly expressed in cardiac endothelial cells during ischemia, has an unclear role in barrier function during...
2.
Lange M, Francis C, Furtado J, Kim Y, Liao J, Eichmann A
bioRxiv
. 2024 Nov;
PMID: 39605538
Background: The Rho kinases 1 and 2 (ROCK1/2) are serine-threonine specific protein kinases that control actin cytoskeleton dynamics. They are expressed in all cells throughout the body, including cardiomyocytes, smooth...
3.
Fukuma N, Tokiwa H, Numata G, Ueda K, Liu P, Tajima M, et al.
Cardiovasc Res
. 2024 Sep;
120(15):1884-1897.
PMID: 39259833
Aims: Oestrogen exerts beneficial cardiovascular effects by binding to specific receptors on various cells to activate nuclear and non-nuclear actions. Oestrogen receptor α (ERα) non-nuclear signalling confers protection against heart...
4.
Ayata C, Kim H, Morrison L, Liao J, Gutierrez J, Lopez-Toledano M, et al.
Neurol Genet
. 2024 Jan;
10(1):e200121.
PMID: 38179414
Cerebral cavernous malformations (CCMs) are vascular lesions characterized by a porous endothelium. The lack of a sufficient endothelial barrier can result in microbleeds and frank intracerebral hemorrhage. A primary mechanism...
5.
German C, Liao J
Arch Toxicol
. 2023 Apr;
97(6):1529-1545.
PMID: 37084080
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic cardiovascular disease. These medications not only reduce low-density lipoprotein cholesterol (LDL-C) via inhibition of 3-hydroxy-3-methylglutarate attached to CoA reductase,...
6.
Ullah K, Ai L, Li Y, Liu L, Zhang Q, Pan K, et al.
bioRxiv
. 2023 Mar;
PMID: 36993497
Myocardial infarction (MI) significantly compromises the integrity of the cardiac microvascular endothelial barrier, leading to enhanced leakage and inflammation that contribute to the progression of heart failure. While HIF2α is...
7.
Liu P, Fukuma N, Hiroi Y, Kunita A, Tokiwa H, Ueda K, et al.
JACC Basic Transl Sci
. 2023 Feb;
8(1):55-67.
PMID: 36777173
Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in...
8.
Yu B, Osman A, Sladojevic N, Prabhu N, Tai H, Chen D, et al.
JACC CardioOncol
. 2022 Oct;
4(3):371-383.
PMID: 36213346
Background: Second- and third-generation BCR-ABL1 tyrosine kinase inhibitors (TKIs) are associated with cardiovascular adverse events (CVAEs) in patients with Philadelphia chromosome-positive (Ph+) leukemia. Objectives: We hypothesized that second- and third-generation...
9.
Bhattacharya J, Booy R, Casadevall A, Dela Cruz C, Fedson D, Garcia J, et al.
Pharmacol Res Perspect
. 2022 Jul;
10(4):e00988.
PMID: 35837790
No abstract available.
10.
Li Y, Tai H, Sladojevic N, Kim H, Liao J
J Am Heart Assoc
. 2021 Oct;
10(20):e022568.
PMID: 34612053
Background The pathogenesis of vascular stiffening and hypertension is marked by non-compliance of vessel wall because of deposition of collagen fibers, loss of elastin fibers, and increased vascular thickening. Rho/Rho-associated...