James J Hickman
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Explore the profile of James J Hickman including associated specialties, affiliations and a list of published articles.
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110
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3088
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Recent Articles
1.
Patel A, Poddar S, Nierenberg D, Lang S, Wang H, Pires DeMello C, et al.
Curr Res Toxicol
. 2025 Jan;
8():100209.
PMID: 39839141
Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a...
2.
Caneus J, Autar K, Akanda N, Grillo M, Long C, Jackson M, et al.
Sci Rep
. 2024 Oct;
14(1):24875.
PMID: 39438515
Preclinical methods are needed for screening potential Alzheimer's disease (AD) therapeutics that recapitulate phenotypes found in the Mild Cognitive Impairment (MCI) stage or even before this stage of the disease....
3.
Patel A, Williams M, Hawkins K, Gallo L, Grillo M, Akanda N, et al.
ACS Biomater Sci Eng
. 2024 Oct;
10(11):7132-7143.
PMID: 39437333
Myelination and the formation of nodes of Ranvier are essential for the rapid conduction of nerve impulses along axons in the peripheral nervous system (PNS). While many animal-based and serum-containing...
4.
Gallo L, Akanda N, Autar K, Patel A, Cox I, Powell H, et al.
Alzheimers Dement
. 2024 Jul;
20(9):5940-5960.
PMID: 39077965
Introduction: The degeneration of cortical layers is associated with cognitive decline in Alzheimer's disease (AD). Current therapies for AD are not disease-modifying, and, despite substantial efforts, research and development for...
5.
Rupar M, Hanson H, Rogers S, Botlick B, Trimmer S, Hickman J
Lab Chip
. 2024 Jul;
24(15):3604-3625.
PMID: 38957150
This critical review aims to highlight how modeling of the immune response has adapted over time to utilize microphysiological systems. Topics covered here will discuss the integral components of the...
6.
Caneus J, Autar K, Akanda N, Grillo M, Long C, Jackson M, et al.
Res Sq
. 2024 Jun;
PMID: 38826367
Preclinical methods are needed for screening potential Alzheimer's disease (AD) therapeutics that recapitulate phenotypes found in the Mild Cognitive Impairment (MCI) stage or even before this stage of the disease....
7.
Badu-Mensah A, Guo X, Mendez R, Parsaud H, Hickman J
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686322
Although skeletal muscle (hSKM) has been proven to be actively involved in Amyotrophic Lateral Sclerosis (ALS) neuromuscular junction (NMJ) dysfunction, it is rarely considered as a pharmacological target in preclinical...
8.
Guo X, Akanda N, Fiorino G, Nimbalkar S, Long C, Colon A, et al.
Adv Biol (Weinh)
. 2023 Sep;
8(8):e2300276.
PMID: 37675827
Opioid overdose is the leading cause of drug overdose lethality, posing an urgent need for investigation. The key brain region for inspiratory rhythm regulation and opioid-induced respiratory depression (OIRD) is...
9.
Jangir H, Hickman J
ACS Biomater Sci Eng
. 2023 Jul;
9(8):4698-4708.
PMID: 37462389
Microcantilever platforms are functional models for studying skeletal muscle force dynamics in vitro. However, the contractile force generated by the myotubes can cause them to detach from the cantilevers, especially...
10.
Rupar M, Sasserath T, Smith E, Comiter B, Sriram N, Long C, et al.
Sci Rep
. 2023 Jun;
13(1):10509.
PMID: 37380653
A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs...