James J Asciolla
Overview
Explore the profile of James J Asciolla including associated specialties, affiliations and a list of published articles.
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7
Citations
537
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Recent Articles
1.
Asciolla J, Wu X, Adamopoulos C, Gavathiotis E, Poulikakos P
Nat Cancer
. 2025 Jan;
6(1):24-40.
PMID: 39885369
Cyclin-dependent kinases (CDKs) 4 and 6 (CDK4/6) are important regulators of the cell cycle. Selective CDK4/6 small-molecule inhibitors have shown clinical activity in hormonal receptor-positive (HR) metastatic breast cancer, but...
2.
Asciolla J, Resh M
Cell Rep
. 2019 Dec;
29(13):4608-4619.e4.
PMID: 31875564
Attachment of palmitate to the N terminus of Sonic hedgehog (Shh) is essential for Shh signaling. Shh palmitoylation is catalyzed on the luminal side of the endoplasmic reticulum (ER) by...
3.
Cederquist G, Asciolla J, Tchieu J, Walsh R, Cornacchia D, Resh M, et al.
Nat Biotechnol
. 2019 Apr;
37(4):436-444.
PMID: 30936566
Human brain organoids generated with current technologies recapitulate histological features of the human brain, but they lack a reproducible topographic organization. During development, spatial topography is determined by gradients of...
4.
Asciolla J, Miele M, Hendrickson R, Resh M
J Biol Chem
. 2017 Jun;
292(33):13507-13513.
PMID: 28655768
Wnt proteins are a family of secreted signaling proteins that play key roles in regulating cell proliferation in both embryonic and adult tissues. Production of active Wnt depends on attachment...
5.
Serasinghe M, Wieder S, Renault T, Elkholi R, Asciolla J, Yao J, et al.
Mol Cell
. 2015 Feb;
57(3):521-36.
PMID: 25658204
Mitochondrial division is essential for mitosis and metazoan development, but a mechanistic role in cancer biology remains unknown. Here, we examine the direct effects of oncogenic RAS(G12V)-mediated cellular transformation on...
6.
Renault T, Floros K, Elkholi R, Corrigan K, Kushnareva Y, Wieder S, et al.
Mol Cell
. 2014 Dec;
57(1):69-82.
PMID: 25482509
Proapoptotic BCL-2 proteins converge upon the outer mitochondrial membrane (OMM) to promote mitochondrial outer membrane permeabilization (MOMP) and apoptosis. Here we investigated the mechanistic relationship between mitochondrial shape and MOMP...
7.
Asciolla J, Renault T, Chipuk J
J Vis Exp
. 2012 Oct;
(68).
PMID: 23070252
The BCL-2 (B cell CLL/Lymphoma) family is comprised of approximately twenty proteins that collaborate to either maintain cell survival or initiate apoptosis(1). Following cellular stress (e.g., DNA damage), the pro-apoptotic...
8.
Anvekar R, Asciolla J, Missert D, Chipuk J
Front Oncol
. 2012 Jan;
1(34).
PMID: 22268005
The global incidence of melanoma has dramatically increased during the recent decades, yet the advancement of primary and adjuvant therapies has not kept a similar pace. The development of melanoma...