James I Andorko
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Explore the profile of James I Andorko including associated specialties, affiliations and a list of published articles.
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22
Citations
660
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Recent Articles
1.
Cherry C, Andorko J, Krishnan K, Mejias J, Nguyen H, Stivers K, et al.
Geroscience
. 2023 Apr;
45(4):2559-2587.
PMID: 37079217
Cellular senescence is a state of permanent growth arrest that plays an important role in wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells' (SnCs) pathological role and therapeutic...
2.
Maestas Jr D, Chung L, Han J, Wang X, Sommerfeld S, Kelly S, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(8):e2211703120.
PMID: 36780522
The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth soluble egg antigen (SEA) to stimulate production of interleukin...
3.
Andorko J, Tsai S, Gammon J, Carey S, Zeng X, Gosselin E, et al.
Biomater Sci
. 2022 Jul;
10(16):4612-4626.
PMID: 35796247
Recently approved cancer immunotherapies - including CAR-T cells and cancer vaccination, - show great promise. However, these technologies are hindered by the complexity and cost of isolating and engineering patient...
4.
Cherry C, Maestas D, Han J, Andorko J, Cahan P, Fertig E, et al.
Nat Biomed Eng
. 2021 Aug;
5(10):1228-1238.
PMID: 34341534
The understanding of the foreign-body responses to implanted biomaterials would benefit from the reconstruction of intracellular and intercellular signalling networks in the microenvironment surrounding the implant. Here, by leveraging single-cell...
5.
Wang X, Chung L, Hooks J, Maestas Jr D, Lebid A, Andorko J, et al.
Sci Adv
. 2021 Apr;
7(16).
PMID: 33863719
The avascular nature of cornea tissue limits its regenerative potential, which may lead to incomplete healing and formation of scars when damaged. Here, we applied micro- and ultrafine porcine urinary...
6.
Chung L, Maestas Jr D, Lebid A, Mageau A, Rosson G, Wu X, et al.
Sci Transl Med
. 2020 Apr;
12(539).
PMID: 32295900
Medical devices and implants made of synthetic materials can induce an immune-mediated process when implanted in the body called the foreign body response, which results in formation of a fibrous...
7.
Hess K, Oh E, Tostanoski L, Andorko J, Susumu K, Deschamps J, et al.
Adv Funct Mater
. 2018 Mar;
27(22).
PMID: 29503604
Treatments for autoimmunity - diseases where the immune system mistakenly attacks self-molecules - are not curative and leave patients immunocompromised. New studies aimed at more specific treatments reveal development of...
8.
Ory E, Chen D, Chakrabarti K, Zhang P, Andorko J, Jewell C, et al.
Oncotarget
. 2018 Jan;
8(67):111567-111580.
PMID: 29340075
During metastasis, tumor cells dynamically change their cytoskeleton to traverse through a variety of non-adherent microenvironments, including the vasculature or lymphatics. Due to the challenges of imaging drift in non-adhered...
9.
Andorko J, Jewell C
Bioeng Transl Med
. 2017 Sep;
2(2):139-155.
PMID: 28932817
Recent research in the vaccine and immunotherapy fields has revealed that biomaterials have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. Intriguingly, new studies...
10.
Andorko J, Pineault K, Jewell C
J Biomed Mater Res A
. 2016 Dec;
105(4):1219-1229.
PMID: 27977902
Polymeric carriers are ubiquitously studied in vaccine and drug delivery to control the encapsulation, kinetics, and targeting of cargo. Recent research reveals many polymers can cause immunostimulatory and inflammatory responses,...