James H Notwell
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Explore the profile of James H Notwell including associated specialties, affiliations and a list of published articles.
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8
Citations
286
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Recent Articles
1.
Rim E, Garrett O, Howard A, Shim Y, Li Y, Van Dyke J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975188
Rapid development of immune receptors that protect crops from emerging pathogens is a critical challenge . While novel immune receptors that recognize previously undetected pathogen effectors could provide protection against...
2.
Howard A, Rim E, Garrett O, Shim Y, Notwell J, Ronald P
bioRxiv
. 2025 Feb;
PMID: 39974914
Linking sequence variation to phenotypic effects is critical for efficient exploitation of large genomic datasets. Here we present a novel approach combining directed evolution with protein language modeling to characterize...
3.
Heavner W, Ji S, Notwell J, Dyer E, Tseng A, Birgmeier J, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(40):25074-25084.
PMID: 32948690
We are only just beginning to catalog the vast diversity of cell types in the cerebral cortex. Such categorization is a first step toward understanding how diversification relates to function....
4.
Ho H, Both M, Siniard A, Sharma S, Notwell J, Wallace M, et al.
Front Cell Neurosci
. 2018 Jul;
12:159.
PMID: 29970990
Recent advances in single-cell technologies are paving the way to a comprehensive understanding of the cellular complexity in the brain. Protocols for single-cell transcriptomics combine a variety of sophisticated methods...
5.
Madelaine R, Notwell J, Skariah G, Halluin C, Chen C, Bejerano G, et al.
Nucleic Acids Res
. 2018 Mar;
46(7):3517-3531.
PMID: 29518216
Thousands of human disease-associated single nucleotide polymorphisms (SNPs) lie in the non-coding genome, but only a handful have been demonstrated to affect gene expression and human biology. We computationally identified...
6.
Madelaine R, Sloan S, Huber N, Notwell J, Leung L, Skariah G, et al.
Cell Rep
. 2017 Aug;
20(7):1533-1542.
PMID: 28813666
In the developing brain, neurons expressing VEGF-A and blood vessels grow in close apposition, but many of the molecular pathways regulating neuronal VEGF-A and neurovascular system development remain to be...
7.
Notwell J, Heavner W, Fazel Darbandi S, Katzman S, McKenna W, Ortiz-Londono C, et al.
Genome Res
. 2016 Jun;
26(8):1013-22.
PMID: 27325115
Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF) variants in individuals with autism spectrum disorders (ASD), including TBR1, a master regulator of cortical development. We performed...
8.
Notwell J, Chung T, Heavner W, Bejerano G
Nat Commun
. 2015 Mar;
6:6644.
PMID: 25806706
The neocortex is a mammalian-specific structure that is responsible for higher functions such as cognition, emotion and perception. To gain insight into its evolution and the gene regulatory codes that...
9.
Wenger A, Clarke S, Notwell J, Chung T, Tuteja G, Guturu H, et al.
PLoS Genet
. 2013 Sep;
9(8):e1003728.
PMID: 24009522
Genetic studies have identified a core set of transcription factors and target genes that control the development of the neocortex, the region of the human brain responsible for higher cognition....
10.
Hiller M, Agarwal S, Notwell J, Parikh R, Guturu H, Wenger A, et al.
Nucleic Acids Res
. 2013 Jul;
41(15):e151.
PMID: 23814184
Many important model organisms for biomedical and evolutionary research have sequenced genomes, but occupy a phylogenetically isolated position, evolutionarily distant from other sequenced genomes. This phylogenetic isolation is exemplified for...