James G Macfarlane
Overview
Explore the profile of James G Macfarlane including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
150
Followers
0
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Recent Articles
1.
Macfarlane J, Dorward D, Ruchaud-Sparagano M, Scott J, Lucas C, Rossi A, et al.
J Inflamm (Lond)
. 2020 Dec;
17(1):34.
PMID: 33292269
Background: Neutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when acute inflammation proceeds unchecked. A number of key neutrophil functions,...
2.
Pinder E, Rostron A, Hellyer T, Ruchaud-Sparagano M, Scott J, Macfarlane J, et al.
Thorax
. 2018 Aug;
73(10):918-925.
PMID: 30064991
Background: Critically ill patients with impaired neutrophil phagocytosis have significantly increased risk of nosocomial infection. Granulocyte-macrophage colony-stimulating factor (GM-CSF) improves phagocytosis by neutrophils ex vivo. This study tested the hypothesis...
3.
Scott J, Harris G, Pinder E, Macfarlane J, Hellyer T, Rostron A, et al.
J Allergy Clin Immunol
. 2015 Sep;
137(2):535-44.
PMID: 26388312
Background: Neutrophils play a role in the pathogenesis of asthma, chronic obstructive pulmonary disease, and pulmonary infection. Impaired neutrophil phagocytosis predicts hospital-acquired infection. Despite this, remarkably few neutrophil-specific treatments exist....
4.
Hellyer T, Morris A, McAuley D, Walsh T, Anderson N, Singh S, et al.
Thorax
. 2014 Oct;
70(1):41-7.
PMID: 25298325
Background: Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful validation of the...
5.
McDonnell M, Jary H, Perry A, Macfarlane J, Hester K, Small T, et al.
Respir Med
. 2014 Sep;
109(6):716-26.
PMID: 25200914
Background: The hallmark of non-cystic fibrosis bronchiectasis is recurrent bronchial infection, yet there are significant gaps in our understanding of pathogen persistence, resistance and exacerbation frequencies. Pseudomonas aeruginosa is a...
6.
Ruchaud-Sparagano M, Gertig H, Hester K, Macfarlane J, Corris P, Simpson A, et al.
Respirology
. 2013 Jun;
18(8):1230-5.
PMID: 23730995
Background And Objective: Neutrophils are consistently found in inflamed and infected airways in idiopathic bronchiectasis, but relatively little is known about the function of blood neutrophils in this condition. We...
7.
Macfarlane J, Jary H, Hester K, McAlinden P, Wake J, Small T, et al.
Innate Immun
. 2012 Mar;
18(6):787-92.
PMID: 22382779
Deficiency of mannose-binding lectin (MBL), a serum protein involved in killing and promoting phagocytosis of pathogens, is associated with respiratory infection and disease progression in a number of acute and...
8.
Roberts-Thomson P, Jones M, Walker J, Macfarlane J, Smith M, Ahern M
J Rheumatol
. 2002 Dec;
29(12):2628-34.
PMID: 12465164
Objective: Rheumatic disorders arise in certain individuals depending on the interaction of genetic and environmental factors, the contribution for each varying with the specific rheumatic disorder. However, a third variable,...